Ion channel modulating compounds and uses thereof

Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the productio...

Full description

Saved in:
Bibliographic Details
Main Authors Bain, Allen I, Beatch, Gregory N, Longley, Cindy J, Plouvier, Bertrand M. C, Sheng, Tao, Walker, Michael J. A, Wall, Richard A, Yong, Sandro L, Zhu, Jeff Jiqun, Zolotoy, Alexander B
Format Patent
LanguageEnglish
Published 19.05.2009
Online AccessGet full text

Cover

Loading…
Abstract Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
AbstractList Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
Author Zolotoy, Alexander B
Beatch, Gregory N
Longley, Cindy J
Bain, Allen I
Plouvier, Bertrand M. C
Wall, Richard A
Sheng, Tao
Yong, Sandro L
Zhu, Jeff Jiqun
Walker, Michael J. A
Author_xml – sequence: 1
  givenname: Allen I
  surname: Bain
  fullname: Bain, Allen I
– sequence: 2
  givenname: Gregory N
  surname: Beatch
  fullname: Beatch, Gregory N
– sequence: 3
  givenname: Cindy J
  surname: Longley
  fullname: Longley, Cindy J
– sequence: 4
  givenname: Bertrand M. C
  surname: Plouvier
  fullname: Plouvier, Bertrand M. C
– sequence: 5
  givenname: Tao
  surname: Sheng
  fullname: Sheng, Tao
– sequence: 6
  givenname: Michael J. A
  surname: Walker
  fullname: Walker, Michael J. A
– sequence: 7
  givenname: Richard A
  surname: Wall
  fullname: Wall, Richard A
– sequence: 8
  givenname: Sandro L
  surname: Yong
  fullname: Yong, Sandro L
– sequence: 9
  givenname: Jeff Jiqun
  surname: Zhu
  fullname: Zhu, Jeff Jiqun
– sequence: 10
  givenname: Alexander B
  surname: Zolotoy
  fullname: Zolotoy, Alexander B
BookMark eNrjYmDJy89L5WQw9MzPU0jOSMzLS81RyM1PKc1JLMnMS1dIzs8tyC_NSylWSMxLUSgtTi1WKMlILUrNT-NhYE1LzClO5YXS3AwKbq4hzh66pcUFiSWpeSXF8elFiSDKwNzU2MTc0sCYCCUAaRAudQ
ContentType Patent
CorporateAuthor Cardiome Pharma Corp
CorporateAuthor_xml – name: Cardiome Pharma Corp
DBID EFH
DatabaseName USPTO Issued Patents
DatabaseTitleList
Database_xml – sequence: 1
  dbid: EFH
  name: USPTO Issued Patents
  url: http://www.uspto.gov/patft/index.html
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
ExternalDocumentID 07534790
GroupedDBID EFH
ID FETCH-uspatents_grants_075347903
IEDL.DBID EFH
IngestDate Sun Mar 05 22:32:38 EST 2023
IsOpenAccess true
IsPeerReviewed false
IsScholarly false
Language English
LinkModel DirectLink
MergedId FETCHMERGED-uspatents_grants_075347903
OpenAccessLink https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7534790
ParticipantIDs uspatents_grants_07534790
PatentNumber 7534790
PublicationCentury 2000
PublicationDate 20090519
PublicationDateYYYYMMDD 2009-05-19
PublicationDate_xml – month: 05
  year: 2009
  text: 20090519
  day: 19
PublicationDecade 2000
PublicationYear 2009
References Lang et al., "Clinical Evaluation of RSD921 As a Local Anaesthetic in Patients Undergoing Venous Cannulation for Elective Treatment", Clin Pharm & Therapeutics, p. 142, Feb. 2000. Abstract PIII-1.
Roden and George, "The Cardiac Ion Channels: Relevance to Management of Arrhythmias", Annu Rev Med 47:135-148, 1996.
Grant, "Mechanisms of Atrial Fibrillation and Action of Drugs Used in its Management", Am J Cardiol 82:43N-49N, Oct. 16, 1998.
Bain et al. (2007/0004718) 20070100
Wong and Clohs, "Capillary Electrophoresis Assay to Assess In Vitro Metabolic Stability of Novel Compounds in Human Liver Microsomes", Cardiome Pharma Corp., Vancouver, BC, AAPS Poster, Oct. 2001.
Yong et al., "RSD1000: A Novel Antiarrhythmic Agent with Increased Potency Under Acidic and High-Potassium Conditions", J Pharm Exp Ther 289(1):236-244, 1999.
(02-270864) 19901100
Bain et al., "Better Antiarrhythmics? Development of Antiarrhythmic Drugs Selective for Ischaemia-Dependent Arrhythmias", Drug Development Research 42:198-210, 1997.
Clohs, "Capillary Electrophoresis And Its Applications In The Pharmaceutical Industry-Short Course: One Platform Fits Many Applications", CSC 2002, 52 pages.
Lewis et al., "Enzyme inhibition during the conversion of squalene to cholesterol", Steroids 60:475-483, Jul. 1995.
Walker et al., "Increased Electrophysiological Activity in Raised K+ and low pH Improves Antiarrhythmic Efficacy for a Group of Morpholinocyclohexyl Derivatives", BPS Proceedings 118P, 1996.
Cardiome Pharma Corp. (Jan. 17, 2002). "Cardiome Reports Dosing of First Patient in Pivotal Phase II Study" (http://cardiome.com/wordpress/?p=90). Press Release.
Horwell (4598087) 19860700
Orth et al., "The Novel AF Conversion Agent RSD1235 Preferentially Blocks a Late Component of the Human Heart (hH1) Na+ Current Active During Repolarization", EP abstracts Oct. 3, 2003.
Stevenson, "Atrial Fibrillation and Heart Failure-Five More Years", N Engl J Med 351(23):2437-2440, Dec. 2, 2004.
Wat et al., "Effects of Arylbenzacetamides on Neuromuscular Preparation", Proc West Pharmacol Soc 1994.
Clohs, "Pharmacokinetics profiling of new drug candidates: a key process in drug discovery", Beckman Coulter P/ACE Setter 4(1):Jun. 6, 2000.
Beatch et al. (7345087) 20080300
Yong et al., "SAR Evidence that Antiarrhythmic Activity is Unrelated to Opioid Kappa Agonist Activity", BPS Proceedings 117P, 1996.
Nattel et al., "Effects of the novel antiarrhythmic agent azimilide on experimental atrial fibrillation and atrial electrophysiologic properties", Cardiovascular Research 37:627-635, 1998.
Cardiome Pharma Corp. (Jul. 24, 2006). "Cardiome Announces Interim Phase 2A Results for Oral RSD1235" (http://cardiome.com/wordpress/?p=312). Press Release.
Beatch et al., "Characterization of a Non-Human Primate Model of Drug-Induced Torsades De Pointes", Proc West Pharmacol Soc 40:13-16, 1997.
Pugsley et al., "Are the arrhythmias due to myocardial ischaemia and infarction dependent upon the sympathetic system?", Cardiol Res 43:830-831, 1999.
Sum (6649603) 20031100
(720605) 19960700
Halfpenny et al., "Highly Selective k-Opioid Analgesics. 2. Synthesis and Structure-Activity Relationships of Novel N-[(2-Aminocyclohexyl)aryl]acetamide Derivatives", J Med Chem 32:1620-1626, 1989.
Horwell et al. (4663343) 19870500
Beatch et al. (2006/0252753) 20061100
Beatch et al., "Aminocycloalkyl Ether Compounds and Uses Thereof," U.S. Appl. No. 10/977,559, filed Oct. 29, 2004, now abandoned.
Beatch et al. (2007/0197632) 20070800
Nomura et al. (5750537) 19980500
Brown et al. (5817698) 19981000
Fedida et al. (2005/0070552) 20050300
Zhang et al., "Inhibition of [3H]-U69593 binding and the cardiac effects of U50, 488H by calcium channel blockers in the rat heart", Brit J Pharmacol 120:827-832, 1997.
Zolotoy et al., "Physicochemical Determinants for Drug Induced Blockade of HERG Potassium Channels: Effect of Charge and Charge Shielding", Curr Med Chem 1(3): 1-17, 2003.
(2 658 401) 19780700
(WO 99/16431) 19990400
(2132841) 20010300
Moorman et al., "pKa Does Not Predict pH Potentiation of Sodium Channel Blockade by Lidocaine and W6211 in Guinea Pig Ventricular Myuocardium", The Journal of Pharmacology and Experimental Therapeutics 238(1):159-166, 1986.
Hayes et al., "Direct Actions of Arylpiperazines on Rabbit and Human Corpus Caversonal Smooth Muscle In Vitro", Asia Par J Pharmacol, Abstract S15, 1997.
MacLeod et al. (5885984) 19990300
Nakashima et al., "Angiotensin II Type I Receptor Antagonist Prevents the Promotion of Atrial Fibrillation", PACE 24(Part II):698, May 10, 2002. Abstract 701.
Cardiome Pharma Corp. (Dec. 20, 2004). "Cardiome's Pivotal AF Study Achieves Primary Endpoint" (http://cardiome.com/wordpress/?p=14). Press Release.
Yong et al., "Low pKa Predicts Antiarrhythmic Efficacy in a Series of Aminocyclohexyl Esters", J Mol Cell Cardiol. Abstract 057, 1997.
Roy et al., "RSD1235 Rapidly and Effectively Terminates Atrial Fibrillation", Eur Heart J, p. 3699, 2003.
Rynbrandt et al., "Cis-1-[2-(p-Anisidinomethyl)cyclohexyl]piperidine and Related Compounds. Oral Hypoglycemic Agents", J Med Chem 14(10): 985-987, 1971.
Cardiome Pharma Corp. (Feb. 4, 2005). "Cardiome Reports Additional ACT 1 Clinical Results" (http://cardiome.com/wordpress/?p=2). Press Release.
Cardiome Pharma Corp. (Dec. 5, 2002). "Cardiome Reports Oral Absorption of RSD1235 in Humans" (http://cardiome.com/wordpress/?p=72). Press Release.
Beatch et al., "Aminocycloalkyl Ether Compounds and Uses Thereof," U.S. Appl. No. 10/977,343, filed Oct. 29, 2004, now abandoned.
Wang et al., "Effects of Flecainide, Quinidine, and 4-Aminopyridine on Transient Outward and Ultrarapid Delayed Rectifier Currents in Human Atrial Myocytes", J Pharm Exp Ther 272(1):184-196, 1995.
Franciosi et al., "Phase II Clinical Trial of RSD921 as a Local Anaesthetic in Patients Undergoing Venous Cannulation For Elective Treatment", in Proceedings of the 28th Annual ACCP Meeting Abstract 32, p. 977, Feb. 2000.
Bain et al. (7101877) 20060900
Nishi et al., "Studies on 2-Oxoquinoline Derivatives as Blood Platelet Aggregation Inhibitors. IV. Synthesis and Biological Activity of the Metabolites of 6-[4-(1-Cyclohexyl-1H-5-tetrazolyl)butoxy]-2-oxo-1,2,3,4-tetrahydroquinoline (OPC-13013)", Chem. Pharm. Bull 33(3):1140-1147, 1985.
(WO 97/49680) 19971200
Shapiro et al. (3218328) 19651100
Vippagunta et al., Crystalline solids, 2001, Advanced Drug Delivery Reviews, 48, pp. 3 and 18.
MacLeod et al. (5506257) 19960400
(WO 2004/098525) 20041100
Kertesz et al., "The Electrophysiological and Antiarrhythmic Actions of RSD Analogs of U50,488H in Rats", in Proceedings of the West Pharmacol Soc. 9 pages, 1994.
(WO 01/96335) 20011200
Clohs, "CE and Drug Metabolism Studies: A Powerful Combination in Drug Discovery", CE in the Biotechnology and Pharmaceutical Industries (Symposium), Washington, DC, Aug. 2002, 31 pages.
Yong et al., "RSD1000: A Novel Antiarrhythmic Agent with an Improved Therapeutic Index", BPS Proceedings 119P, 1996.
Walker et al., "Determination of an arylacetamide antiarrhythmic in rat blood and tissues using reversed-phase high-performance liquid chromatography", J Chromatog B 675:257-263, 1996.
Li et al., "Adrenergic Modulation of Ultrarapid Delayed Rectifier K+ Current in Human Atrial Myocytes", Circ Res 78(5):903-915, May 1996.
Wolf et al., "Impact of Atrial Fibrillation on Mortality, Stroke, and Medical Costs", Arch Intern Med 158: 229-234, Feb. 9, 1998.
Barrett et al., "Atypical Dose Response Curves for Antiarrhythmic Drugs", BPS Proceedings 115P, 1996.
Beatch et al., "RSD1235 Rapidly and Effectively Terminates Atrial Fibrillation", Abstract submission ESC Congress Aug. 30-Sep. 3, 2003, in Vienna, Austria.
Clohs and Wong, "Validation of a capillary electrophoresis assay for assessing the metabolic stability of verapamil in human liver microsomes", J Cap Elec & Microchip Tech. 007(5/6):113-117, 2002.
(WO 95/28155) 19951000
Beatch et al., "Electrophysiological Profile of RSD1235, A New Drug for Conversion of Atrial Fibrillation", Abstract of U.S. Appl. No. 10/674,684, filed Sep. 29, 2003, now U.S. Patent No. 7,101,877 issued Sep. 5, 2006.
Orth et al., "Cyclopentane-1-amines", Chemical Abstracts 89(15):555, Abstract No. 129113f, 1978.
Horwell et al. (4906655) 19900300
Amin et al., "RPR 101821, a New Potent Cholesterol-lowering Agent: Inhibition of Squalene Synthase and 7-Dehydrocholesterol Reductase", Naunyn-Schmiedeberg's Arch Pharmacol 353:233-240, 1996.
Fedida et al. (2005/0119315) 20050600
Jung et al. (2007/0254945) 20071100
Nattel et al., "The Role of Channel Opening in Transient Outward Current Bock By Quinidine, Flecainide, and 4-Aminopyridine in Human Atrial Myocytes", K Channels II: Regulation and Block, Abstract No. Tu-Pos403, 1994.
Ribeiro et al., "Determination of RSD921 in human plasma by high-performance liquid chromatography-tandem mass spectrometry using tri-deuterated RSD921 as internal standard: application to a phase I clinical trial", J Mass Spectrom 36:1133-1139, 2001.
Valenzuela et al., "Effects of Ropivacaine on a Potassium Channel (hKv1.5) Cloned from Human Ventricle", Anesthesiology 86:718-728, 1997.
Wang et al., "Sustained Depolarization-Induced Outward Current in Human Atrial Myocytes", Circ. Res. 73(6):1061-1076, Dec. 1993.
Bowen et al., "Characterization of the Enantiomers of cis-N-[2-(3,4-Dichlorophenyl)Ethyl]-N-Methyl-2-(1-Pyrrolidinyl)Cyclohexylamine (BD737 and BD738): Novel Compounds with High Affinity, Selectivity and Biological Efficacy at Sigma Receptors", J Pharmacol Exp Ther 262(1):32-40, 1992.
Barrett, "Ischemia Selective Electrophysiological and Antiarrhythmic Actions of RSD1019 in Ischemic Cardiac Tissue", J Mol Cell Cardiol 29:197, 1997.
Yeola et al., "Molecular Analysis of a Binding Site for Quinidine in a Human Cardiac Delayed Rectifier K+ Channel"-Role of S6 in Antiarrhythmic Drug Binding, Circ Res 78(6): 1105-1114, Jun. 1996.
(WO 03/105756) 20031200
Friess et al., "Central Activity Evoked in the Cat by Cis-Trans Isomers of 1,2-Aminocyclohexanol Dervivatives", Taxicol Appl Pharmacol 3:638-653, 1961.
Rich et al
References_xml – year: 20070800
  ident: 7259184
  contributor:
    fullname: Beatch et al.
– year: 19960200
  ident: 5492825
  contributor:
    fullname: Jan et al.
– year: 19930900
  ident: WO 93/19056
– year: 19900600
  ident: 2004575
– year: 19970900
  ident: 5670335
  contributor:
    fullname: Jan et al.
– year: 20010100
  ident: 6174879
  contributor:
    fullname: MacLeod et al.
– year: 19900800
  ident: 380063
– year: 20050300
  ident: 2005/0070552
  contributor:
    fullname: Fedida et al.
– year: 20070800
  ident: 2007/0197632
  contributor:
    fullname: Beatch et al.
– year: 19950300
  ident: 2172513
– year: 19951000
  ident: WO 95/28155
– year: 19900300
  ident: 4906655
  contributor:
    fullname: Horwell et al.
– year: 19900600
  ident: 372466
– year: 20011200
  ident: WO 01/96335
– year: 19600900
  ident: 2954380
  contributor:
    fullname: Shapiro et al.
– year: 19960700
  ident: 720605
– year: 19791200
  ident: 4179501
  contributor:
    fullname: Szmuszkovicz
– year: 19940400
  ident: WO 94/07843
– year: 19870500
  ident: 4663343
  contributor:
    fullname: Horwell et al.
– year: 20061100
  ident: 2006/0252753
  contributor:
    fullname: Beatch et al.
– year: 19851200
  ident: 3 517 901
– year: 20040100
  ident: WO 2004/008103
– year: 19990100
  ident: 2289055
– year: 19890800
  ident: 4855316
  contributor:
    fullname: Horwell et al.
– year: 20050200
  ident: 2005/0038256
  contributor:
    fullname: Barrett et al.
– year: 19990300
  ident: 5885984
  contributor:
    fullname: MacLeod et al.
– year: 19651100
  ident: 3218328
  contributor:
    fullname: Shapiro et al.
– year: 19980500
  ident: 5750537
  contributor:
    fullname: Nomura et al.
– year: 19790300
  ident: 4145435
  contributor:
    fullname: Szmuszkovicz
– year: 20041100
  ident: WO 2004/099137
– year: 19870400
  ident: 4656182
  contributor:
    fullname: Horwell
– year: 19971200
  ident: WO 97/49680
– year: 20031200
  ident: WO 03/105756
– year: 20060600
  ident: 7057053
  contributor:
    fullname: Beatch et al.
– year: 19891100
  ident: 4880800
  contributor:
    fullname: Wallis et al.
– year: 19960800
  ident: WO 96/23894
– year: 19880400
  ident: 1235122
– year: 20010400
  ident: 6214810
  contributor:
    fullname: Fermini et al.
– year: 19990400
  ident: WO 99/16431
– year: 20000800
  ident: WO 00/47547
– year: 19950300
  ident: WO 95/08544
– year: 20050600
  ident: 2005/0119315
  contributor:
    fullname: Fedida et al.
– year: 19911000
  ident: 5059620
  contributor:
    fullname: Stout et al.
– year: 20070100
  ident: 2007/0004718
  contributor:
    fullname: Bain et al.
– year: 19990100
  ident: WO 99/03468
– year: 19960400
  ident: 5506257
  contributor:
    fullname: MacLeod et al.
– year: 20010100
  ident: 6180632
  contributor:
    fullname: Myers et al.
– year: 19980300
  ident: 5734021
  contributor:
    fullname: Lester et al.
– year: 19930600
  ident: 2058502
– year: 19950200
  ident: 215963
– year: 20071100
  ident: 2007/0254945
  contributor:
    fullname: Jung et al.
– year: 19940700
  ident: WO 94/14435
– year: 19910900
  ident: 5051428
  contributor:
    fullname: Horwell et al.
– year: 19780700
  ident: 2 658 401
– year: 19860700
  ident: 4598087
  contributor:
    fullname: Horwell
– year: 19990300
  ident: WO 99/11252
– year: 20060900
  ident: 7101877
  contributor:
    fullname: Bain et al.
– year: 20000900
  ident: WO 00/51981
– year: 20060500
  ident: 7053087
  contributor:
    fullname: Beatch et al.
– year: 19960600
  ident: WO 96/18615
– year: 19971200
  ident: 2008391
– year: 19981000
  ident: 5817698
  contributor:
    fullname: Brown et al.
– year: 19880400
  ident: 1234808
– year: 19900300
  ident: 147085
– year: 19870500
  ident: 222533
– year: 19901100
  ident: 02-270864
– year: 19991000
  ident: WO 99/50205
– year: 20010400
  ident: 6210809
  contributor:
    fullname: Okutomi et al.
– year: 19980300
  ident: 5728535
  contributor:
    fullname: Lester et al.
– year: 19740600
  ident: 2 259 260
– year: 19970600
  ident: 5637583
  contributor:
    fullname: MacLeod et al.
– year: 20031100
  ident: 6649603
  contributor:
    fullname: Sum
– year: 20041100
  ident: WO 2004/098525
– year: 20080300
  ident: 7345087
  contributor:
    fullname: Beatch et al.
– year: 20070500
  ident: 2007/0099983
  contributor:
    fullname: Barrett et al.
– year: 20020900
  ident: 6451819
  contributor:
    fullname: Alanine et al.
– year: 19910500
  ident: 5019588
  contributor:
    fullname: Horwell et al.
– year: 19990100
  ident: WO 99/02159
– year: 20030200
  ident: 6521619
  contributor:
    fullname: Link et al.
– year: 19970900
  ident: WO 97/32857
– year: 20080300
  ident: 7345086
  contributor:
    fullname: Beatch et al.
– year: 19991000
  ident: WO 99/50225
– year: 19930700
  ident: 552386
– year: 19970700
  ident: 2244209
– year: 20010300
  ident: 2132841
– year: 20001000
  ident: 2268590
– year: 20051200
  ident: 6979685
  contributor:
    fullname: Beatch et al.
Score 2.7325249
Snippet Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also...
SourceID uspatents
SourceType Open Access Repository
Title Ion channel modulating compounds and uses thereof
URI https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7534790
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1NSwMxEB1qEdSTomL9Igev0axNNuYsXVZB6UGht5Jtkl7apDS7-PedZKV40WsCw4RkMm_IyxuAuySJpozVtHxkmuIJEVRzWVIMK-4WUixU1pl9ey_rT_46E7MB1Lu_MGsMI7pBX-J9FzdtyORKvN77jae9-HPSCPRJfeDLr4I2U-MeEHZzqbB433tiido3qeojOEATCNl8G38ljeoY9qd59AQG1p9C8RI8Sf9svV2RdTC5b5ZfkkTqTr2NIsGinnTRRpJAmQ3uDEg1-Xiu6c7-fLlNvJU5-_FjfA5DrN_tBRA51ggzCs2Mctxoq6yQTaGUc7oRTDcjGP1p5vKfuSs47J82BC3UNQzbbWdvMEO2zW1e_jdiDXF7
link.rule.ids 230,309,783,805,888,64375
linkProvider USPTO
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT8MwDLamgWCcQIDYeOXANdCyplHOsKrjMfUA0m5VuiS7bMm0tOLv47Ro4gLXRLKsJI5t-fNngLtAiSaUljR9jCTFF8KoTHhK0awSs-BsIVqe2fdZmn8mL3M270G-64VZoxnRDeri7xu_qV0LrsTvvbt42pE_B45AG9gHvuzKSVUo84Bhd8IFJu97oRQVwH2TLD-CQxSCQZut_S-3kR3DftGunkBP21OIp86S0Glr9YqsnWonZ9klCbDuMN3IE0zrSeO1JyEs086cAckmH0853ckvl9uAXCmjH03G59DHDF5fAOFjiYFGLCMlTKKkFprxKhbCGFmxSFZDGP4pZvTP3i0cFM9Z-TadvV7CoKtzMBqLK-jX20Zfo7usq5v2JL4BHnF0dw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=Ion+channel+modulating+compounds+and+uses+thereof&rft.inventor=Bain%2C+Allen+I&rft.inventor=Beatch%2C+Gregory+N&rft.inventor=Longley%2C+Cindy+J&rft.inventor=Plouvier%2C+Bertrand+M.+C&rft.inventor=Sheng%2C+Tao&rft.inventor=Walker%2C+Michael+J.+A&rft.inventor=Wall%2C+Richard+A&rft.inventor=Yong%2C+Sandro+L&rft.inventor=Zhu%2C+Jeff+Jiqun&rft.inventor=Zolotoy%2C+Alexander+B&rft.number=7534790&rft.date=2009-05-19&rft.externalDBID=n%2Fa&rft.externalDocID=07534790