Process for manufacturing of chiral lobelin
The present invention relates to a shortened process for preparing L-lobeline by rhodium-catalysed asymmetric hydrogenation on an industrial scale.
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Main Authors | , |
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Format | Patent |
Language | English |
Published |
31.03.2009
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Online Access | Get full text |
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Abstract | The present invention relates to a shortened process for preparing L-lobeline by rhodium-catalysed asymmetric hydrogenation on an industrial scale. |
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AbstractList | The present invention relates to a shortened process for preparing L-lobeline by rhodium-catalysed asymmetric hydrogenation on an industrial scale. |
Author | Klingler, Franz-Dietrich Sobotta, Rainer |
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CorporateAuthor | Boehringer Ingelheim Pharma GmbH & Co. KG |
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References | Ojima et al. "Synthesis of chiral dipeptides . . . " CA 96:123292 (1982). Wieland (1946345) 19340200 Kriz et al. "Preparation of lobeline . . . " CA 114:247574 (1991). Bellus et al. "Lobelia alkaloids . . . " CA 61:11490 (1964). Takeda et al. "Practical asymmetric synthesis . . . " Tetrahedron Lett. 30(3) p. 367-370 (1989). Sakuraba et al. "An efficient synthesis of . . . " Tetrahedron Assymmetry v.4, issue 7, abstract (1993). |
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Snippet | The present invention relates to a shortened process for preparing L-lobeline by rhodium-catalysed asymmetric hydrogenation on an industrial scale. |
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Title | Process for manufacturing of chiral lobelin |
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