Process for manufacturing of chiral lobelin

The present invention relates to a shortened process for preparing L-lobeline by rhodium-catalysed asymmetric hydrogenation on an industrial scale.

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Bibliographic Details
Main Authors Klingler, Franz-Dietrich, Sobotta, Rainer
Format Patent
LanguageEnglish
Published 31.03.2009
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Abstract The present invention relates to a shortened process for preparing L-lobeline by rhodium-catalysed asymmetric hydrogenation on an industrial scale.
AbstractList The present invention relates to a shortened process for preparing L-lobeline by rhodium-catalysed asymmetric hydrogenation on an industrial scale.
Author Klingler, Franz-Dietrich
Sobotta, Rainer
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CorporateAuthor Boehringer Ingelheim Pharma GmbH & Co. KG
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References Ojima et al. "Synthesis of chiral dipeptides . . . " CA 96:123292 (1982).
Wieland (1946345) 19340200
Kriz et al. "Preparation of lobeline . . . " CA 114:247574 (1991).
Bellus et al. "Lobelia alkaloids . . . " CA 61:11490 (1964).
Takeda et al. "Practical asymmetric synthesis . . . " Tetrahedron Lett. 30(3) p. 367-370 (1989).
Sakuraba et al. "An efficient synthesis of . . . " Tetrahedron Assymmetry v.4, issue 7, abstract (1993).
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Snippet The present invention relates to a shortened process for preparing L-lobeline by rhodium-catalysed asymmetric hydrogenation on an industrial scale.
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Title Process for manufacturing of chiral lobelin
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