Multicyclic sulfonamide compounds as inhibitors of histone deacetylase for the treatment of disease

Disclosed herein are carbonyl compounds of Formula I as described herein. Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disord...

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Main Authors Malecha, James William, Noble, Stewart Alwyn, Hassig, Christian Andreus, Wash, Paul L, Wiley, Brandon M, Lawrence, Charles Maxwell, Hoffman, Timothy Z
Format Patent
LanguageEnglish
Published 30.12.2008
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Abstract Disclosed herein are carbonyl compounds of Formula I as described herein. Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
AbstractList Disclosed herein are carbonyl compounds of Formula I as described herein. Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
Author Hassig, Christian Andreus
Lawrence, Charles Maxwell
Hoffman, Timothy Z
Wiley, Brandon M
Wash, Paul L
Noble, Stewart Alwyn
Malecha, James William
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References (2006063294) 20060600
(2007067994) 20070600
Matsuo et al. (5034417) 19910700
Malecha (2006/0030554) 20060200
Satoh et al. (2003/0229126) 20031200
(2007016354) 20070200
Joseph E. Payne; Inhibitors of Histone Deacetylase for the Treatment of Disease; U.S. Appl. No. 11/608,736, filed Dec. 8, 2006 (not yet published); Kalypsys, Inc.
McEvoy et al. (4226775) 19801000
Matsuo et al. (4866091) 19890900
Adachi (3660542) 19720500
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Snippet Disclosed herein are carbonyl compounds of Formula I as described herein. Methods and compositions are disclosed for treating disease states including, but not...
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