Nucleic acid molecules encoding osteoclastogenesis inhibitory factor proteins

A protein which inhibits osteoclast differentiation and/or maturation and a method for producing the protein. The protein is produced by human embryonic lung fibroblasts and has a molecular weight of about 60 kD and about 120 kD under non-reducing conditions and about 60 kD under reducing conditions...

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Main Authors Goto, Masaaki, Tsuda, Eisuke, Mochizuki, Shin'ichi, Yano, Kazuki, Kobayashi, Fumie, Shima, Nobuyuki, Yasuda, Hisataka, Nakagawa, Nobuaki, Morinaga, Tomonori, Ueda, Masatsugu, Higashio, Kanji
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LanguageEnglish
Published 23.12.2008
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Abstract A protein which inhibits osteoclast differentiation and/or maturation and a method for producing the protein. The protein is produced by human embryonic lung fibroblasts and has a molecular weight of about 60 kD and about 120 kD under non-reducing conditions and about 60 kD under reducing conditions on SDS-polyacrylamide gel electrophoresis. The protein can be isolated and purified from the culture medium of fibroblasts. Furthermore, the protein can be produced by gene engineering. The present invention includes cDNA for producing the protein by gene engineering, antibodies having specific affinity for the protein or a method for determining protein concentration using these antibodies.
AbstractList A protein which inhibits osteoclast differentiation and/or maturation and a method for producing the protein. The protein is produced by human embryonic lung fibroblasts and has a molecular weight of about 60 kD and about 120 kD under non-reducing conditions and about 60 kD under reducing conditions on SDS-polyacrylamide gel electrophoresis. The protein can be isolated and purified from the culture medium of fibroblasts. Furthermore, the protein can be produced by gene engineering. The present invention includes cDNA for producing the protein by gene engineering, antibodies having specific affinity for the protein or a method for determining protein concentration using these antibodies.
Author Goto, Masaaki
Tsuda, Eisuke
Kobayashi, Fumie
Mochizuki, Shin'ichi
Yano, Kazuki
Ueda, Masatsugu
Higashio, Kanji
Shima, Nobuyuki
Morinaga, Tomonori
Yasuda, Hisataka
Nakagawa, Nobuaki
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  fullname: Tsuda, Eisuke
– sequence: 3
  givenname: Shin'ichi
  surname: Mochizuki
  fullname: Mochizuki, Shin'ichi
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  givenname: Kazuki
  surname: Yano
  fullname: Yano, Kazuki
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  givenname: Fumie
  surname: Kobayashi
  fullname: Kobayashi, Fumie
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  givenname: Nobuyuki
  surname: Shima
  fullname: Shima, Nobuyuki
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  givenname: Hisataka
  surname: Yasuda
  fullname: Yasuda, Hisataka
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  givenname: Nobuaki
  surname: Nakagawa
  fullname: Nakagawa, Nobuaki
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  givenname: Tomonori
  surname: Morinaga
  fullname: Morinaga, Tomonori
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  givenname: Masatsugu
  surname: Ueda
  fullname: Ueda, Masatsugu
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  givenname: Kanji
  surname: Higashio
  fullname: Higashio, Kanji
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Snippet A protein which inhibits osteoclast differentiation and/or maturation and a method for producing the protein. The protein is produced by human embryonic lung...
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SourceType Open Access Repository
Title Nucleic acid molecules encoding osteoclastogenesis inhibitory factor proteins
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