Insect chymotrypsin and inhibitors thereof
Helicoverpa armigera Helicoverpa punctigera Nicotiana alata. Helicoverpa The present invention relates generally to a novel chymotrypsin that exhibits resistance to a plant serine proteinase inhibitor. More particularly, the present invention provides a chymotrypsin which is up-regulated in the gut...
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Language | English |
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09.12.2008
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Abstract | Helicoverpa armigera Helicoverpa punctigera Nicotiana alata. Helicoverpa The present invention relates generally to a novel chymotrypsin that exhibits resistance to a plant serine proteinase inhibitor. More particularly, the present invention provides a chymotrypsin which is up-regulated in the gut of and insect larvae when fed the serine proteinase inhibitors of The novel chymotrypsin represents, therefore, a target for the identification of antagonists including inhibitors which are proposed to be useful in the control of spp. populations that have become resistant to serine proteinase inhibitors produced in plants. The antagonists of the chymotrypsin may be topically applied to the plants or, when in proteinaceous form, may be produced by genetic means in plant cells. The antagonists may act at the level of gene expression or protein activity. |
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AbstractList | Helicoverpa armigera Helicoverpa punctigera Nicotiana alata. Helicoverpa The present invention relates generally to a novel chymotrypsin that exhibits resistance to a plant serine proteinase inhibitor. More particularly, the present invention provides a chymotrypsin which is up-regulated in the gut of and insect larvae when fed the serine proteinase inhibitors of The novel chymotrypsin represents, therefore, a target for the identification of antagonists including inhibitors which are proposed to be useful in the control of spp. populations that have become resistant to serine proteinase inhibitors produced in plants. The antagonists of the chymotrypsin may be topically applied to the plants or, when in proteinaceous form, may be produced by genetic means in plant cells. The antagonists may act at the level of gene expression or protein activity. |
Author | Dunse, Kerry Michelle Anderson, Marilyn Anne Heath, Robyn Louise |
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References | (WO 84/03564) 19840900 Inoue et al., Gene 96: 23-28 (1990). Bonner and Laskey, Eur. J. Biochem. 46:83 (1974). Combet et al., TIBS. 25: 147-150 (2000). Johnston et al., Insect Biochem. 2(4)1: 389-397 (1991). Beuning and Christeller, Plant Physiol 102:1061 (1993). Hodgson, Bio/Technology 9: 19-21 (1991). Hediger et al., Insect Mol. Biol. 10: 113-119 (2001). Johnston et al., Insect Biochem. Molec. Biol. 25(3): 375-383 (1995). Greenblatt et al., J. Mol. Biol. 205: 201 (1989). Keil et al., EMBO J. 8: 1323-1330 (1989). Volpicella et al., Eur. J. Biochem. 270: 10-19 (2003). Summerton et al., Antisense and Nucleic Acid Drug Development 7: 187-195 (1997). Hjelmeland et al., Comparative Biochemistry and Physiology B 71: 557-562 (1982). Broadway and Duffey, J. Insect Physiol. 32(8):673-680 (1986a). Erickson et al., Science 249: 527-533 (1990). Pathirana et al., Plant J. 12(2): 293-304 (1997). Peterson et al., Insect Biochem. Mol. Biol. 25(7): 765-774 (1995). (WO 97/02048) 19970100 Sakal et al., International Journal of Peptide and Protein Research 34: 498-505 (1989). Linthorst et al., Plant Mol. Biol. 21: 985-992 (1993). Miller et al., Plant Mol. Biol. 42: 329-333 (2000). Atkinson et al., The Plant Cell 5:203-213 (1993). Heath et al., J. Insect Physiol. 43(9): 833-842 (1997). Samac et al., Plant Cell 3: 1063-1072 (1991). Beuning, L. L., et al., "Evolution of the proteinase inhibitor I family and apparent lack of hypervariability in the proteinase contact loop," J Mol Evol 39:644-654 (1994). Broadway, J. Insect. Physiol. 41: 107-116 (1995). Moura et al., Plant Physiol. 126: 289-298 (2001). Pesole, Trends Genet 15(9): 378 (1999). Nielson et al., Biochemistry 34: 14304-14311 (1995). Fang et al., Plant Cell 1: 141-150 (1989). Sanford et al. (4945050) 19900700 Balandin et al., Plant Mol. Biol. 27:1197-1204 (1995). Graham et al., J. Biol. Chem. 260: 6555-6560 (1985). Gatehouse et al., Insect Biochem. Molecul. Biol. 27(11): 929-944 (1997). EMBL [Online] "Zea may MPI gene" XP002395903, retrieved from EBI accession No. EM-PRO:ZMMPI, Database accession No. X78988 (abstract) (1994). Hsu et al., Plant. Sci. 143: 63-70 (1999). Markwick et al., J. Economic Entomology 91 (6): 1265-76 (1998). Mazumdar-Leighton and Broadway, Insect Biochem. Mol. Biol. 31: 633-644 (2001b). Bradford, Anal Biochem 72:248-254 (1976). Pujade-Renaud et al., Plant Physiol. Biochem. 35(2): 85-93 (1997). Christeller et al., Insect Biochem. Molecul. Biol. 22: 735-746 (1992). Markwick et al., J. Economic Entomology 88(1): 33-39 (1995). Cleveland et al., Plant Mol. Biol. 8: 199-207 (1987). Peloquin et al., J. Cot. Sci. 5: 114-120 (2001). Terra et al., Comp. Biochem. Physiol. 109B: 1-61 (1994). Wu et al., Molecular Breeding 3: 371-380 (1997). Altschul et al., Nucl. Acids Res. 25:3389-3402 (1997). Nielson et al., J. Mol. Biol. 242: 231-243 (1994). Marmur et al., J. Mol. Biol. 5: 109-118 (1962). Stewart and Hsu, Planta 137: 113-117 (1977). Broadway and Duffey, J. Insect Physiol. 32(10):827-833 (1986b). EMBL [Online] "S. tuberosum proteinase inhibitor I." XP002395905, retrieved from EBI accession No. EM-PRO:STPROINI, Database accession No. Z12611 (abstract) (1992). Valaitis et al., Insect Biochemistry and Molecular Biology 29: 405-415 (1999). Patankar et al., Insect Biochem. & Mol. Biol. 31: 453-464 (2001). Lee et al., Nature Structural Biology 6(6): 526-530 (1999). Choi et al., Biochem. et Biophys. Acta 1492: 211-215 (2000). Heath et al., European Journal of Biochemistry 230(1): 250-257 (1995). Cordero et al., The Plant Journal 6(2): 141-150 (1994). Miller et al., Plant Cell 11: 1499-1508 (1999). Xu et al., J. Econ. Entomol. 87(2): 334-338 (1994). Lozovskaya et al., Genetics 142: 173-177 (1996). Greer, Proteins 7: 317-34 (1990). Gatehouse et al., In: Plant Genetic Manipulation for Crop Protection, Biotech. In Agriculture No. 7, Eds. Gatehouse, Hilder & Boulter, International U.K., pp. 155-181 (1992). Antcheva et al., Protein Sci. 10:2280-2290 (2001). Harsulkar et al., Plant Physiol. 121: 497-506 (1999). Ryan, Annu. Rev. Phytopathol. 28: 425-449 (1990). Burgess et al., Entomol. Exp. App. 61: 123-130 (1991). Paulillo et al., J. Econ. Entomol. 93(3): 892-896 (2000). Cripps et al., J. Cell. Biol. 126: 689-699 (1994). Lidholm et al., Genetics 134: 859-868 (1993). Broadway, J. Insect. Physiol. 43(9): 855-874 (1997). Lee et al., Insect. Biochem. Molec. Biol. 25(1): 63-71 (1995a). Taylor et al., Plant Mol. Biol. 23: 1005-1014 (1993). Umbek et al., Biotechnology 5: 263-266 (1987). Stomp et al. (5122466) 19920600 Mazumdar-Leighton and Broadway, Insect Biochem. Mol. Biol. 31: 645-657 (2001a). EMBL [Online] "Tomato leaf wound-induced proteinase inhibitor I Mrna, complete cds." XP002395902, retrieved from EBI accession No. EM-PRO:LEWIPI, Database accession No. K03290 (abstract) (1986). Botos et al., J. Mol. Biol. 298:895-901 (2000). (WO 94/13810) 19940600 Wells, Methods Enzymol. 202: 390-411 (1991). (3135541) 19830300 Ausubel et al., "Current Protocols in Molecular Biology," John Wiley & Sons Inc., Chapter 15 (1994-1998). Schoenbeck et al., Molec. Plant-Microbe Interact 12(10) 882-893 (1999). Broadway, Arch. Insect Biochem. Physiol. 32(1): 39-53 (1996). EMBL [Online] "Nicotiana tabacum mRNA for pre-pro-proteinase inhibitor I (PI-Ia gene)" XP002395904, retrieved from EBI accession No. EM-PRO:NTPII4PI, Database accession No. Z12619 (abstract) (1992). Legavre et al., In: 5th International Congress of Plant Molecular Biology, Singapore 15:3 Supp., Kluwer Academic Publishers (1997). Gatehouse et al., J. Insect Physiol. 45(6): 545-558 (1999). Hajdukiewicz et al., Plant Mol. Biol. 25: 989-994 (1994). Richardson et al., FEBS Letters 52(1): 161 (1975). Johnson, R. et al., Proceedings of the National Academy of Sciences of USA, National Academy of Science, Washington, DC, US, 86:24, pp. 9871-9875 (1989). Bevan, Nucl. Acids Research 12:8711-8721 (1984). Bown, et al., Insect Biochem. Molec. Biol. 27:625-638 (1997). Teakle et al., Journal of Invertebrate Pathology 46: 166-173 (1985). De Leo et al., Plant Physiol. 118: 997-1004 (1998). Jongsma et al., Proc. Natl. Acad. Sci. USA 92(17): 8041-8045 (1995a). Broadway and Villani, Entomol. Expo. Appl. 76:303-312 (1995). Seemuller et al., Hoppe Seyler's Z. Physiol. Chem 358: 1105-1117 (1977). Lee et al., Insect. Biochem. Molec. Biol. 25(1): 49-61 (1995b). |
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