7-phenyl-isoquinoline-5-sulfonylamino derivatives as inhibitors of akt (protein kinase B)

The present invention relates to compounds Formula (I) as inhibitors of AKT activity, which are useful for the treatment of susceptible neoplasms and viral infections.

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Bibliographic Details
Main Authors Barda, David Anthony, Henry, Jr, Kenneth James, Huang, Jianping, Joseph, Sajan, Lin, Ho-Shen, Richett, Michael Enrico
Format Patent
LanguageEnglish
Published 11.11.2008
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Abstract The present invention relates to compounds Formula (I) as inhibitors of AKT activity, which are useful for the treatment of susceptible neoplasms and viral infections.
AbstractList The present invention relates to compounds Formula (I) as inhibitors of AKT activity, which are useful for the treatment of susceptible neoplasms and viral infections.
Author Lin, Ho-Shen
Huang, Jianping
Henry, Jr, Kenneth James
Joseph, Sajan
Richett, Michael Enrico
Barda, David Anthony
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  givenname: Michael Enrico
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References Ikegaki et al. (5747507) 19980500
(WO 2004/094386) 20041100
Reuveni, Hadas, et al., "Toward a PKB Inhibitor: Modification of a Selective PKA Inhibitor by Rational Design," Biochemistry, vol. 41, No. 32, pp. 10304-10314 (2002); XP002267237.
Hidaka et al. (4525589) 19850600
(WO 2005/011697) 20050200
(WO 02/083064) 20021000
(WO 01/64238) 20010900
(WO 02/50019) 20020600
Hidaka et al. (4678783) 19870700
(WO 01/91754) 20011200
(0 520 336) 19920600
(06 100540) 19940400
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Snippet The present invention relates to compounds Formula (I) as inhibitors of AKT activity, which are useful for the treatment of susceptible neoplasms and viral...
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Title 7-phenyl-isoquinoline-5-sulfonylamino derivatives as inhibitors of akt (protein kinase B)
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