Methods of obtaining a specific binding member that binds eotaxin

Specific binding members directed to eotaxin-1, in particular human antibodies and antibody fragments against human eotaxin-1 and especially those which neutralise eotaxin-1 activity. The antibodies VH and/or VL domain of the scFv fragment herein termed CAT-212 and of the IgG4 antibody herein termed...

Full description

Saved in:
Bibliographic Details
Main Authors Vaughan, Tristan John, Wilton, Alison Jane, Smith, Stephen, Main, Sarah Helen
Format Patent
LanguageEnglish
Published 29.01.2008
Online AccessGet full text

Cover

Abstract Specific binding members directed to eotaxin-1, in particular human antibodies and antibody fragments against human eotaxin-1 and especially those which neutralise eotaxin-1 activity. The antibodies VH and/or VL domain of the scFv fragment herein termed CAT-212 and of the IgG4 antibody herein termed CAT 213. One or more complementary determing regions (CDRs) of the CAT-212/-213 VH and/or VL domains, especially VH CRD3 in other antibody framework regions. Compositions containing specific binding members, and their use in methods of inhibiting or neutralising eotaxin, including methods of treatment of the human or animal body by therapy.
AbstractList Specific binding members directed to eotaxin-1, in particular human antibodies and antibody fragments against human eotaxin-1 and especially those which neutralise eotaxin-1 activity. The antibodies VH and/or VL domain of the scFv fragment herein termed CAT-212 and of the IgG4 antibody herein termed CAT 213. One or more complementary determing regions (CDRs) of the CAT-212/-213 VH and/or VL domains, especially VH CRD3 in other antibody framework regions. Compositions containing specific binding members, and their use in methods of inhibiting or neutralising eotaxin, including methods of treatment of the human or animal body by therapy.
Author Wilton, Alison Jane
Main, Sarah Helen
Smith, Stephen
Vaughan, Tristan John
Author_xml – sequence: 1
  givenname: Tristan John
  surname: Vaughan
  fullname: Vaughan, Tristan John
– sequence: 2
  givenname: Alison Jane
  surname: Wilton
  fullname: Wilton, Alison Jane
– sequence: 3
  givenname: Stephen
  surname: Smith
  fullname: Smith, Stephen
– sequence: 4
  givenname: Sarah Helen
  surname: Main
  fullname: Main, Sarah Helen
BookMark eNrjYmDJy89L5WRw9E0tychPKVbIT1PITypJzMzLzEtXSFQoLkhNzkzLTFZIysxLAQnlpuYmpRYplGQkloDFihVS80sSKzLzeBhY0xJzilN5oTQ3g4Kba4izh25pcUFiSWpeSXF8elEiiDIwNzYyNjY0NCZCCQC3BDPz
ContentType Patent
CorporateAuthor Cambridge Antibody Technology Limited
CorporateAuthor_xml – name: Cambridge Antibody Technology Limited
DBID EFH
DatabaseName USPTO Issued Patents
DatabaseTitleList
Database_xml – sequence: 1
  dbid: EFH
  name: USPTO Issued Patents
  url: http://www.uspto.gov/patft/index.html
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
ExternalDocumentID 07323311
GroupedDBID EFH
ID FETCH-uspatents_grants_073233113
IEDL.DBID EFH
IngestDate Sun Mar 05 22:31:26 EST 2023
IsOpenAccess true
IsPeerReviewed false
IsScholarly false
Language English
LinkModel DirectLink
MergedId FETCHMERGED-uspatents_grants_073233113
OpenAccessLink https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7323311
ParticipantIDs uspatents_grants_07323311
PatentNumber 7323311
PublicationCentury 2000
PublicationDate 20080129
PublicationDateYYYYMMDD 2008-01-29
PublicationDate_xml – month: 01
  year: 2008
  text: 20080129
  day: 29
PublicationDecade 2000
PublicationYear 2008
References Harlow et al. Antibodies, A Laboratory Manual. 1988 by Cold Spring Harbor Laboratory. pp. 560-562.
Genbank Acc. No. BAA08370 Eotaxin (Internet website-ncbi.nlm.nih.gov).
Jose et al., "Eotaxin: A Potent Eosinophil Chemoattractant Cytokine Detected in a Guinea Pig Model of Allergic Airways Inflammation," J. Exp. Med. 179:881-887 (Mar. 1, 1994).
Bensimon et al. "Human Lupus Anti-DNA Autoantibodies Undergo Essentially Primary V X Gene Rearrangements," EMBRO J., 13(13):2951-2962 (1994).
(97/12914) 19970400
Pech et al., "Organization and Evolution of a Gene Cluster for Human Immunoglobulin Variable Regions of the Kappa Type," J. Mol. Biol., 176(2):189-204 (1984).
(WO 91/07492) 19910500
(02/02640) 20020100
(2350612) 20000600
Kitaura et al., "Molecular Cloning of Human Eotaxin, an Eosinophil-selective CC Chemokine and Identification of a Specific Eosinophil Eotaxin Receptor, CC Cehmokine Receptor 3," J. Biol. Chem. 271:7725 (1996).
(01/14424) 20010300
(99/10534) 19990300
(93/02190) 19930200
Ewert et al. Methods. 2004 34:184-199.
Williams et al. (5993814) 19991100
Williams et al. (6031080) 20000200
Vaughan et al. (6946546) 20050900
(0 546 634) 19930600
Luster et al. (6403782) 20020600
D. Griffiths-Johnson et al., "The Chemokine, Eotaxin, Activates Guinea-Pig Eosinophils In Vitro and Causes Their Accumulation into the Lung In Vivo" Biochem. & BioPhys. Res. Comm. 197:1167-1172 (Dec. 30, 1993).
(97/00960) 19970100
Ponath et al., "Cloning of the Human Eosinophil Chemoattractant , Eotaxin Expression, Receptor Binding and Functional Properties Suggest a Mechanism for the Selective Recruitment of Eosinophils," J. Clin. Invest. 97:604-612 (1996).
Li et al. Biochemistry 2000. 39:6296-6309.
Garcia-Zepeda et al., "Human Eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia," Nat. Med. 4:449-456 (Apr. 1996).
Jose et al., "Eotaxin: Cloning of an Eosinophil Chemoattractant Cytokine and Increased mRNA Expression in Allergen-Challenged Guinea-Pig Lungs," Biochem & BioPhys. Res. Comm. 205(1):788-794 (Nov. 30, 1994).
Nakajima et al., "Intracellular Localization and Release of Eotaxin from Normal Eosinophils," FEBS Letters, 20625:226-230 (1998).
References_xml – year: 19991100
  ident: 5993814
  contributor:
    fullname: Williams et al.
– year: 19990300
  ident: 99/10534
– year: 19970100
  ident: 97/00960
– year: 20000600
  ident: 2350612
– year: 20010300
  ident: 01/14424
– year: 19930200
  ident: 93/02190
– year: 20000200
  ident: 6031080
  contributor:
    fullname: Williams et al.
– year: 20020600
  ident: 6403782
  contributor:
    fullname: Luster et al.
– year: 19910500
  ident: WO 91/07492
– year: 19970400
  ident: 97/12914
– year: 20050900
  ident: 6946546
  contributor:
    fullname: Vaughan et al.
– year: 19930600
  ident: 0 546 634
– year: 20020100
  ident: 02/02640
Score 2.699299
Snippet Specific binding members directed to eotaxin-1, in particular human antibodies and antibody fragments against human eotaxin-1 and especially those which...
SourceID uspatents
SourceType Open Access Repository
Title Methods of obtaining a specific binding member that binds eotaxin
URI https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7323311
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1NSwMxEB1qEbQnRcX6RQ5eo5tN3d0ci3RZhEoPCr2VZHdWC3ZTuin6851kpXjR6wSSISGZPHhvHsBtlkmBmAiOcUYARdYpV6YueZSUtZBVpOLgDTh9TorX0dP8Yd6DYqeFWdE14mvKpb3btmtnA7mSnvfu4HnX_Nn3CGx894HP5sPqalbV96mMpfQi370s8tSuSV4M4ICmoC9b49pfRSM_gv1ZiB5DD5sTGE-DWXPLbM2scZ0zA9PMax09X4eZZVCYsBV6kw7m3rULsZahdfpr2ZwCyycvjwXfrbd423geyyL6yUueQZ_wPJ4D05WWwqBJTalG0ihTpammSkJIJyHAiEMY_jnNxT9jl3DYkRkEj9UV9N1mi9dUMZ25CdvxDZ0MdsM
link.rule.ids 230,309,786,808,891,64396
linkProvider USPTO
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV07T8MwED5VBUGZQIAoTw-shiQuSTwiaBQerTKA1C2yExsqtUnVuCo_n7ODKhZYz9L55Nf5k-67D-A6jpmvVOhTFcQIUJiOKJe6oF5YaJ-VHg-cNuBoHKbvg-fJ3aQD6YYLM8drRBcYS3OzahamdsWV-Ly3G0_b5s-2R2Bluw-sq1ktyqzUtxELGLMk3y2bY-1ZHybpHuyiE_y0Vab5lTaSfdjOnPUAOqo6hPuRk2tuSK1JLU2rzUAEsWxHW7FD5NRxTMhcWZkOYj6FcbaGqNqIr2l1BCQZvj2kdDNf_rG0lSy59xMZO4YuInp1AkSUgvlSyUgWfMAkl2UUCcwliHVChIyqD_0_3Zz-M3YFO9ljkr8-jV_OoNdWNvg04OfQNcuVusD0aeSlW5lvmyB5vw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=Methods+of+obtaining+a+specific+binding+member+that+binds+eotaxin&rft.inventor=Vaughan%2C+Tristan+John&rft.inventor=Wilton%2C+Alison+Jane&rft.inventor=Smith%2C+Stephen&rft.inventor=Main%2C+Sarah+Helen&rft.number=7323311&rft.date=2008-01-29&rft.externalDBID=n%2Fa&rft.externalDocID=07323311