Fused tri and tetra-cyclic pyrazole kinase inhibitors

Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

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Main Authors Tong, Yunsong, Claiborne, Akiyo K, Li, Gaoquan, Lin, Nan-Horng, Sham, Hing L, Sowin, Thomas J, Tao, Zhi-Fu
Format Patent
LanguageEnglish
Published 22.01.2008
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Abstract Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
AbstractList Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
Author Claiborne, Akiyo K
Sham, Hing L
Tao, Zhi-Fu
Sowin, Thomas J
Lin, Nan-Horng
Tong, Yunsong
Li, Gaoquan
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References Yue et al., "Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 3. Structure activity relationships at C31,2" J. Med. Chem. 45:5233-5248 (2002).
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Title Fused tri and tetra-cyclic pyrazole kinase inhibitors
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