CCK-1 receptor modulators
Certain imidazole compounds are CCK1 modulators useful in the treatment of CCK1 mediated diseases.
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Format | Patent |
Language | English |
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31.07.2007
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Abstract | Certain imidazole compounds are CCK1 modulators useful in the treatment of CCK1 mediated diseases. |
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AbstractList | Certain imidazole compounds are CCK1 modulators useful in the treatment of CCK1 mediated diseases. |
Author | Sehon, Clark A Hack, Michael D Breitenbucher, J. Guy |
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References | Meanwell (5011851) 19910400 Peter et al. Digestive Disease 2006, 24, 70-82. Wolfe, J.P. et al. Simple Efficient Catalyst System for the Palladium-Catalyzed Amination of Aryl Chlorides, Bromides, and Triflates. J. Org. Chem. 2000, 65(4), 1158-1174. (WO 0185724) 20011100 Beers et al. (5965583) 19991000 Meanwell, N.A. et al. Nonprostanoid Prostacyclin Mimetics. 3. Structural Variations of the Diphenyl Heterocycle Moiety. J. Med. Chem. 1992, 35, 3498-3512. (WO 0138324) 20010500 International Search Report dated May 23, 2005, for corresponding international application PCT/US2004/043191. (WO 0190078) 20011100 Wachter et al. (5164381) 19921100 Saito, T. et al. Total Synthesis of the Furaquinocins. J. Am. Chem. Soc. 1998, 120(45), 11633-11644. (WO 9205148) 19920400 (WO 0166539) 20010900 Harper, E.A. et al. Analysis of Variation in L-365,260 Competition Curves in Radioligand Binding Assays. Br. J. Pharmacol. 1996, 118, 1717-1726. Morton, M.F. et al. Pharmacological Comparison of the Alternatively Spliced Short and Long CCK2 Receptors. Br. J. Pharmacol. 2003, 140(1), 218-224. (WO 9901449) 19990100 (WO 01/85723) 20011100 Gigoux, V. et al. Arginine 336 and Asparagine 333 of the Human Cholecystokinin-A Receptor Binding Site Interact with the Penultimate Aspartic Acid and the C-Terminal Amide of Cholecystokinin. J. Biol. Chem. 1999, 274(29), 20457-20464. Wang, Z. A New Synthesis for Methyl 2-Benzyloxyphenylacetate. Synth. Commun. 1999, 29(13), 2361-2364. Crawley, J.N. ESI Special Topics, Oct. 2001; http://www.esi-topics.com/schizophrenia/interviews/dr-jacqueline-n-crawley.html. Murray et al. (5051518) 19910900 (WO 9712876) 19970400 Selnick et al. (5717100) 19980200 Liverton et al. (6083949) 20000700 Hull, R.A. et al. 2-Naphthalenesulphonyl L-aspartyl-(2-phenethyl)amide (2-NAP)-A Selective Cholecystokinin CCKA-Receptor Antagonist. Br. J. Pharmacol. 1993, 108, 734-740. Laufer, S.A. et al. Imidazole Inhibitors of Cytokine Release: Probing Substituents in the 2 Position. J. Med. Chem. 2002, 45, 4695-4705. Klapars, A. et al. A General and Efficient Copper Catalyst for the Amidation of Aryl Halides and the N-Arylation of Nitrogen Heterocycles. J. Am. Chem. Soc. 2001, 123(31), 7727-7729. (0293220) 19940800 (WO 9711704) 19970400 (0442448) 19910800 Klausner, Y.S. and M. Bodzansky. The Azide Method in Peptide Synthesis: Its Scope and Limitations. Synthesis 1974, 8, 549-559. Wachter et al. (4826868) 19890500 de Tullio, P. et al. Therapeutic and Chemical Developments of Cholecystokinin Receptor Ligands. Exp. Opin. Invest. Drugs 2000, 9(1), 129-146. (WO 04/07463) 20040100 |
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