Amorphous substance of tricyclic triazolobenzazepine derivative

HHHHDisclosed are 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5), 10-dioxo-2-1,2,3-triazolo[4,5-c][1]benzazepine, which has been rendered amorphous and possesses improved absorption and dissoluvability, and a pharmaceutical composition comprising the same. Also disclosed are processes...

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Main Authors Ishikura, Toyoaki, Ishizawa, Takayuki, Suemune, Kenji, Ishiwata, Mayumi, Udagawa, Chikako
Format Patent
LanguageEnglish
Published 12.06.2007
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Abstract HHHHDisclosed are 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5), 10-dioxo-2-1,2,3-triazolo[4,5-c][1]benzazepine, which has been rendered amorphous and possesses improved absorption and dissoluvability, and a pharmaceutical composition comprising the same. Also disclosed are processes for producing 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5), 10-dioxo-2-1,2,3-triazolo[4,5-c][1]benzazepine, which has been rendered amorphous, and a pharmaceutical composition comprising the same.
AbstractList HHHHDisclosed are 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5), 10-dioxo-2-1,2,3-triazolo[4,5-c][1]benzazepine, which has been rendered amorphous and possesses improved absorption and dissoluvability, and a pharmaceutical composition comprising the same. Also disclosed are processes for producing 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5), 10-dioxo-2-1,2,3-triazolo[4,5-c][1]benzazepine, which has been rendered amorphous, and a pharmaceutical composition comprising the same.
Author Suemune, Kenji
Ishizawa, Takayuki
Ishiwata, Mayumi
Udagawa, Chikako
Ishikura, Toyoaki
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  givenname: Chikako
  surname: Udagawa
  fullname: Udagawa, Chikako
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References Ohtsuka et al. (6372735) 20020400
Hancock et al. (Pharmaceutical Research, vol. 17, No. 4, 2000).
(99/16770) 19990400
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Snippet HHHHDisclosed are 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5), 10-dioxo-2-1,2,3-triazolo[4,5-c][1]benzazepine, which has been rendered...
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Title Amorphous substance of tricyclic triazolobenzazepine derivative
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