Urocortin proteins and uses thereof
A human urocortin-related peptide with significant sequence homology to the CRF neuropeptide family was identified. A mouse cDNA was isolated from whole brain poly (A+) RNA that encodes a predicted 38 amino acid peptide protein designated herein as urocortin II. Both human URP and mouse Ucn II are s...
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Format | Patent |
Language | English |
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29.05.2007
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Abstract | A human urocortin-related peptide with significant sequence homology to the CRF neuropeptide family was identified. A mouse cDNA was isolated from whole brain poly (A+) RNA that encodes a predicted 38 amino acid peptide protein designated herein as urocortin II. Both human URP and mouse Ucn II are structurally related to the other known mammalian family members, CRF and urocortin (Ucn). These peptides are involved in the regulation of the hypothalamic-pituitary-adrenal axis under basal and stress conditions, suggesting a similar role for URP and Ucn II. Synthesized Ucn-II and URP peptide binds with higher affinity to CRF-R2 than to CRF-R1 Ucn II and human URP appear to be involved in the regulation of body temperature and appetite and may play a role in other stress related phenomenon. These findings identify Ucn II and human URP as a new members of the CRF family of neuropeptides, which are expressed centrally and bind to CRF-R2. |
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AbstractList | A human urocortin-related peptide with significant sequence homology to the CRF neuropeptide family was identified. A mouse cDNA was isolated from whole brain poly (A+) RNA that encodes a predicted 38 amino acid peptide protein designated herein as urocortin II. Both human URP and mouse Ucn II are structurally related to the other known mammalian family members, CRF and urocortin (Ucn). These peptides are involved in the regulation of the hypothalamic-pituitary-adrenal axis under basal and stress conditions, suggesting a similar role for URP and Ucn II. Synthesized Ucn-II and URP peptide binds with higher affinity to CRF-R2 than to CRF-R1 Ucn II and human URP appear to be involved in the regulation of body temperature and appetite and may play a role in other stress related phenomenon. These findings identify Ucn II and human URP as a new members of the CRF family of neuropeptides, which are expressed centrally and bind to CRF-R2. |
Author | Sawchenko, Paul E Vaughan, Joan M Hogenesch, John B Vale, Jr, Wylie Walker Rivier, Jean E F Lewis, Kathy A Reyes, Teresa M Perrin, Marilyn H |
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References | (WO 02/34934) 20020500 Hsu and Hsueh, "Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor," Nature Medicine 7: 605-611, May 2001. GenBank Database, Accession No. BE622276, Oct. 20, 2000. Hsu, S.Y. et al., "Stresscopins and Their Uses," U.S. Appl. No. 60/276,615, filed Mar. 15, 2001. (WO 97/00063) 19970100 Hsu (2002/0082409) 20020600 Isfort et al. (2003/0165807) 20030900 Reyes, T.M. et al., "Urocortin II: A Member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors," Proc. Natl. Acad. Sci. USA 98(5): 2843-2848, Feb. 27, 2001. GenBank Database, Accession No. AC005903, Jan. 9, 2003. GenBank Database, Accession No. AF331517, Mar. 6, 2001. Lewis, K. et al., "Identificiation of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor," Proc. Natl. Acad. Sci. USA 98(13): 7570-7575, Jun. 19, 2001. Hsu, S.Y. et al., "Stresscopins and Their Uses," U.S. Appl. No. 60/244,128, filed Oct. 26, 2000. |
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