Imidazoquinoline derivatives and their use as adenosine A3 ligands

3 The present invention relates to adenosine Areceptor ligands of the general formula (I), within those preferably antagonists, as well as their salts, solvates and isomers, and the pharmaceutical compositions containings them, to the use of the compounds of the general formula (I), as well as their...

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Main Authors Arányi, Péter, Balázs, László, Balogh, Mária, Bátori, Sándor, Boér, Kinga, Gerber, Katalin, Kapui, Zoltán, Mikus, Endre, Tímári, Geza, Lajos, T. Nagy, Urbán-Szabó, Katalin, Szeredi, Judit Vargáné
Format Patent
LanguageEnglish
Published 13.02.2007
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Abstract 3 The present invention relates to adenosine Areceptor ligands of the general formula (I), within those preferably antagonists, as well as their salts, solvates and isomers, and the pharmaceutical compositions containings them, to the use of the compounds of the general formula (I), as well as their salts, solvates and isomers, to the preparation of the compounds of the general formula (I) and their salts, solvates and isomers, furthermore to the new intermediates of the general formulae (II) and (III) and to the preparation thereof.
AbstractList 3 The present invention relates to adenosine Areceptor ligands of the general formula (I), within those preferably antagonists, as well as their salts, solvates and isomers, and the pharmaceutical compositions containings them, to the use of the compounds of the general formula (I), as well as their salts, solvates and isomers, to the preparation of the compounds of the general formula (I) and their salts, solvates and isomers, furthermore to the new intermediates of the general formulae (II) and (III) and to the preparation thereof.
Author Lajos, T. Nagy
Tímári, Geza
Arányi, Péter
Bátori, Sándor
Mikus, Endre
Urbán-Szabó, Katalin
Gerber, Katalin
Balázs, László
Boér, Kinga
Szeredi, Judit Vargáné
Kapui, Zoltán
Balogh, Mária
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References Ager et al. (4279912) 19810700
Aranyi et al. (2005/0234056) 20051000
Clements-Jewery, Stephen et al., J. Med. Chem., vol. 31(6), pp. 1220-1226 (1988).
Barnes et al. (4333934) 19820600
Kadin (4075343) 19780200
Tilley et al., "Adenosine and inosine increase cutaneous vasopermeability by activating A3 receptors on mast cells", The journal of clinical investigation, 2000, vol. 105, pp. 361-367.
Ager, Ian R. et al., J. Med. Chem., vol. 31(6), pp. 1098-1115 (1988).
Shneyvays et al., "Insights into adenosine A1 and A3 receptors function: cardiotoxicity and cardioprotection", Drug development research, vol. 50, pp. 324-337.
(0062580) 19821000
Barnes et al. (4387098) 19830600
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Snippet 3 The present invention relates to adenosine Areceptor ligands of the general formula (I), within those preferably antagonists, as well as their salts,...
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Title Imidazoquinoline derivatives and their use as adenosine A3 ligands
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