Crystalline forms of carbapenem antibiotics and methods of preparation

• Main Authors: Brands, Karel M. J, Cvetovich, Raymond, Crocker, Louis S, Ward, Michael D, Mahajan, Amar J, Wenslow, Robert M, Williams, John M, Sidler, Daniel R, Orella, Charles, Fisher, Elizabeth S, Jobson, Ronald
• Format: Patent
• Language: English
• Published: 05.12.2006

2-5 A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than −5° C., c) adjusting the pH using a solution conta...