Crystalline forms of carbapenem antibiotics and methods of preparation

2-5 A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than −5° C., c) adjusting the pH using a solution conta...

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Main Authors Brands, Karel M. J, Cvetovich, Raymond, Crocker, Louis S, Ward, Michael D, Mahajan, Amar J, Wenslow, Robert M, Williams, John M, Sidler, Daniel R, Orella, Charles, Fisher, Elizabeth S, Jobson, Ronald
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LanguageEnglish
Published 05.12.2006
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Abstract 2-5 A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than −5° C., c) adjusting the pH using a solution containing an acid in an organic solvent to give the appropriate pH for crystallization, and d) crystallizing the compound by adding methanol, and a Calcohol at between −5 and −25° C.
AbstractList 2-5 A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than −5° C., c) adjusting the pH using a solution containing an acid in an organic solvent to give the appropriate pH for crystallization, and d) crystallizing the compound by adding methanol, and a Calcohol at between −5 and −25° C.
Author Jobson, Ronald
Mahajan, Amar J
Brands, Karel M. J
Crocker, Louis S
Williams, John M
Fisher, Elizabeth S
Sidler, Daniel R
Ward, Michael D
Cvetovich, Raymond
Wenslow, Robert M
Orella, Charles
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