Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48

• Main Authors: Andersen, Henrik Sune, Hansen, Thomas Kruse, Iversen, Lars Fogh, Lau, Jesper, Møller, Niels Peter Hundahl, Olsen, Ole Hvilsted, Axe, Frank Urban, Ge, Yu, Holsworth, Daniel Dale, Jones, Todd Kevin, Judge, Luke Milburn, Ripka, Wiliam Charles, Shapira, Barry Zvi, Uyeda, Roy Teruyuki
• Format: Patent
• Language: English
• Published: 03.10.2006

The present invention provides a method of inhibiting a member of a family of Protein Tyrosine Phosphatases (PTPases, PTPs) such as PTP1B, TC-PTP, CD45, SHP-1, SHP-2, PTPα, PTPε, PTPμ, PTPδ, PTPσ, PTPζ, PTPβ, PTPD1, PTPD2, PTPH1, PTP-MEG1, PTP-LAR, and HePTP by exposing said Ptpase member by adminis...