Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade

The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.

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Bibliographic Details
Main Authors South, Michael S, Webber, Ronald K, Huang, Horng-Chih, Toth, Mihaly V, Moormann, Alan E, Snyder, Jeffery S, Scholten, Jeffrey A, Garland, Danny J, Rueppel, Melvin L, Neumann, William L, Long, Scott, Huang, Wei, Trujillo, John, Parlow, John J, Jones, Darin E, Case, Brenda, Hayes, Michael J
Format Patent
LanguageEnglish
Published 12.09.2006
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Summary:The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.