Hepatitis C inhibitor tri-peptides
1 2 233 23 4 Compounds of formula (I): wherein Ris hydroxyl or sulfonamide derivative; Ris t-butyl or -CH-C(CH)or -CH-cyclopentyl; Ris t-butyl or cyclohexyl and Ris cyclobutyl, cyclopentyl or cyclohexyl; or a pharmaceutically acceptable salt thereof, are described as useful as inhibitor of the HCV N...
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Format | Patent |
Language | English |
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15.08.2006
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Abstract | 1 2 233 23 4 Compounds of formula (I): wherein Ris hydroxyl or sulfonamide derivative; Ris t-butyl or -CH-C(CH)or -CH-cyclopentyl; Ris t-butyl or cyclohexyl and Ris cyclobutyl, cyclopentyl or cyclohexyl; or a pharmaceutically acceptable salt thereof, are described as useful as inhibitor of the HCV NS3 protease. |
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AbstractList | 1 2 233 23 4 Compounds of formula (I): wherein Ris hydroxyl or sulfonamide derivative; Ris t-butyl or -CH-C(CH)or -CH-cyclopentyl; Ris t-butyl or cyclohexyl and Ris cyclobutyl, cyclopentyl or cyclohexyl; or a pharmaceutically acceptable salt thereof, are described as useful as inhibitor of the HCV NS3 protease. |
Author | Llinas-Brunet, Montse Bailey, Murray D Ghiro, Elise |
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References | (WO 02/08251) 20020100 Huang, et al; "Olefin Metathesis-Active Ruthenium Complexes Bearing a Nucleophilic Carbene Ligand"; J. Am. Chem. Soc. 1999, 121, pp. 2674-2678. Miller, et al; "Application of Ring-Closing Metathesis to the Synthesis of Rigidified Amino Acids and Peptides"; J. Am. Chem. Soc. 1996, 118, pp. 9606-9614. Sibal et al. 2001, ILAR Journal, vol. 42, No. 2, pp. 74-84. (WO 00/09543) 20000200 Krchnak, et al; "Polymer-Supported Mitsunobu Ether Formation and its Use in Combinatorial Chemistry"; Tetrahedron Ltrs., vol. 36, No. 35, pp. 6193-6916, 1995. (WO 00/31129) 20000200 (WO 98/46630) 19981000 Mitsunobu; "The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products"; Synthesis (Reviews), pp. 1-28. Derwent Abstract: AN 1999-350322 [30] (JP 11127861). (WO 01/32691) 20010500 (WO 98/22496) 19980500 Derwent Abstract: AN 1999-040664 [04] (JP 10298151). (WO 01/64678) 20010900 Derwent Abstract: AN 2000-018687 [02] (JP 11292840). (WO 98/46597) 19981000 (WO 99/38888) 19990800 (WO 01/40262) 20010600 (WO 00/59929) 20001000 (WO 97/43310) 19971100 Hurst et al. (6187905) 20010200 (WO 02/060926) 20020800 (WO 99/64442) 19991200 Derwent Abstract AN 1999-186214 [16] (JP 11035478). (WO 02/08244) 20020100 (2 337 262) 19991100 (WO 02/18369) 20020300 (WO 99/50230) 19991000 (WO 00/09558) 20000200 (WO 01/74768) 20011000 (11-35478) 19990200 (WO 99/07733) 19990200 (WO 98/17679) 19980400 (WO 02/079234) 20021000 (WO 02/08198) 20020100 (11-137252) 19990500 (11-292840) 19991000 (WO 01/58929) 20010800 (WO 01/16357) 20010300 Derwent Abstract: AN 2001-435746 [47] (JP2001103993). (WO 02/08187) 20020100 Still, et al; "Rapid Chromatographic Technique for Preparative Separations with Moderate Resolution"; J. Org. Chem. 1978. vol. 43, No. 14, pp. 2923-2925. Derwent Abstract AN 1999-374374 [32] (JP 11137252). Priestley (2004/0147483) 20040700 (WO 00/20400) 20000400 (2001-103993) 20010400 (10-298151) 19981100 Gyorkos et al. (6159938) 20001200 (WO 02/08256) 20020100 (WO 01/81325) 20011100 (WO 01/77113) 20011000 Rano, et al; "Solid Phase Synthesis of Aryl Ethers Via the Mitsunobu Reaction"; Tetrahedron Ltrs., 1995, vol. 36, No. 22, pp. 3789-3792. Lohmann, et al; "Replication of Subgenomic Hepatitis C Virus RNAs in a Hepatoma Cell Line"; Science. 1999. vol. 285. pp. 110-113. (11-127861) 19990500 (WO 99/07734) 19990200 Kingsbury, et al; "A Recyclable Ru-Based Metathesis Catalyst"; J. Am. Chem. Soc. 1999, 121, pp. 791-799. (WO 01/02424) 20010100 (WO 01/07407) 20010200 Llinas-Brunet et al. (6323180) 20011100 |
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Snippet | 1 2 233 23 4 Compounds of formula (I): wherein Ris hydroxyl or sulfonamide derivative; Ris t-butyl or -CH-C(CH)or -CH-cyclopentyl; Ris t-butyl or cyclohexyl... |
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Title | Hepatitis C inhibitor tri-peptides |
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