Vitamin B12 and pemetrexed disodium combination therapies
A method of administering an antifolate to a mammal in need thereof, comprising administering an effective amount of said antifolate in combination with a methylmalonic acid lowering agent.
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Main Authors | , , |
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Format | Patent |
Language | English |
Published |
30.05.2006
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Online Access | Get full text |
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Abstract | A method of administering an antifolate to a mammal in need thereof, comprising administering an effective amount of said antifolate in combination with a methylmalonic acid lowering agent. |
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AbstractList | A method of administering an antifolate to a mammal in need thereof, comprising administering an effective amount of said antifolate in combination with a methylmalonic acid lowering agent. |
Author | Niyikiza, Clet Paoletti, Paolo Rusthoven, James Jacob |
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CorporateAuthor | Eli Lilly and Company |
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References | Worzolla, et al. (Anticancer Research, (1998) 18: 3235-3240). Pitman (2004/0005311) 20040100 Arsenyan et al. (Abstract ; Onkol. Nauchn., (1978) 12(10): 49-54). Calvert, H., "Folate status and the safety profile of antifolates," Seminars In Oncology, 29/2, Suppl. 5 (3-7) (2002); XP08005755. Thompson (2920015) 19600100 Waralla, et al., "Role of folic acid in modulating the toxicity and efficacy of the multitargeted antifolate, LY231514," Anticancer Research, 18(5A), 3235-3239 (1998) ; XP008005757. Westerhef, et al., "Carrier- and receptor-mediated transport of folate antagonists targeting folate dependent exzymes: correlates of molecular-structure and biological activity," Mol. Pharmacol., 48(3), 459-471 (1995) ; XP008005762. Francis et al. (5736402) 19980400 John, et al. (Cancer 2000, 88: 1807-13). Hanauske, et al., "Premetrexed Disodium: A novel antitolate clinically active againstmultiple solid tumors," Oncologist Alphamed Press, US, vol. 4, No. 4, (2001) pp. 363-373; XP008005752. Allen et al. (5563126) 19961000 Bunn, et al., "Vitamin B12 and folate reduce toxicity of alimta (pemetrexed disodium, LY231514, MTA), A novel antifolate/antimetabolite," Program/ Proceedings-American Society of Clinical Oncology, The Society, US, vol. 76A, No. 20 (2001) p. 3000; XP008005885. Hanauske, et al., "Premetrexed Disodium: A novel antitolate clinically active againstmultiple solid tumors," Oncologist, Alphamed Press, US, vol. 4, No. 6, (2001) pp. 363-373; XP008005752. Allen et al. (6528496) 20030300 Allen et al. (2003/0225030) 20031200 Westerhef, et al., "Carrier and receptor-mediated transport of folate antagonists targeting folate dependent exzymes: corselates of molecular-structure and biological activity," Mol. Pharmcol., 48 (3), 459-471 (1995) ; XP008005762. Toraya et al. (5405839) 19950400 Ohmori et al. (5431925) 19950700 Allen et al. (6297224) 20011000 Allen et al. (6207651) 20010300 Allen et al. (2003/0216350) 20031100 Runn, et al., "Vitamin B12 and tolate reduce toxicity of alimta (pemetrexed disodium, LY233514, MTA), A novel antifolate/antimetabolite," Program/ Proceedings-American Society of Clinical Oncology, The Society, US, vol. 76A, No. 20 (2001) p. 300; XP008005885. Warralla, et al., " Role of folic acid in modulating the toxicity and efficacy of the multitargeted antifolate, LY231514," Anticancer Research, 18(5A), 3235-3239 (1998) ; XP008005757. Calvert, H., "Future directions in the development of pemetrexed," Seminars In Oncology, 29/2 Suppl. 5 (54-61) (2002) ; XP009005744. (0 546 870) 19930600 Dierkes et al., Supplementation with Vitamin B12 Decreases Homocystein and Methylmalonic Acid but Also Serum Folate in Patients with End-Stage Renal Disease. Metabolism. May 1999. vol. 48, No. 5, pp. 631-635. See: abstract. |
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