Vitamin B12 and pemetrexed disodium combination therapies

A method of administering an antifolate to a mammal in need thereof, comprising administering an effective amount of said antifolate in combination with a methylmalonic acid lowering agent.

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Main Authors Niyikiza, Clet, Paoletti, Paolo, Rusthoven, James Jacob
Format Patent
LanguageEnglish
Published 30.05.2006
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Abstract A method of administering an antifolate to a mammal in need thereof, comprising administering an effective amount of said antifolate in combination with a methylmalonic acid lowering agent.
AbstractList A method of administering an antifolate to a mammal in need thereof, comprising administering an effective amount of said antifolate in combination with a methylmalonic acid lowering agent.
Author Niyikiza, Clet
Paoletti, Paolo
Rusthoven, James Jacob
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Warralla, et al., " Role of folic acid in modulating the toxicity and efficacy of the multitargeted antifolate, LY231514," Anticancer Research, 18(5A), 3235-3239 (1998) ; XP008005757.
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Dierkes et al., Supplementation with Vitamin B12 Decreases Homocystein and Methylmalonic Acid but Also Serum Folate in Patients with End-Stage Renal Disease. Metabolism. May 1999. vol. 48, No. 5, pp. 631-635. See: abstract.
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Title Vitamin B12 and pemetrexed disodium combination therapies
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