Cross-reactive monoclonal and polyclonal antibodies which recognize surface proteins from coagulase-negative staphylococci and Staphylococcus aureus

S. aureus S. epidermidis S. hemolyticusS. aureus Polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positive staphylococcus bacteria, such as and to coagulase-negative bacteria, such as and , are provided which can recognize surface proteins from both coagulase-positive...

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Main Authors Foster, Timothy, Roche, Fiona, Pallen, Mark, Patti, Joseph M, Hutchins, Jeff T, Speziale, Pietro
Format Patent
LanguageEnglish
Published 11.01.2005
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Abstract S. aureus S. epidermidis S. hemolyticusS. aureus Polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positive staphylococcus bacteria, such as and to coagulase-negative bacteria, such as and , are provided which can recognize surface proteins from both coagulase-positive and coagulase negative staph bacteria. The antibodies may be generated from surface proteins that have been isolated on the basis of characteristics that may be common between and coagulase-negative staphylococci, and these recombinant surface proteins are used to generate the antibodies of the invention. There is also provided vaccines and methods which utilize these proteins and antibodies for the treatment or protection against a wide variety of staphylococcal infections.
AbstractList S. aureus S. epidermidis S. hemolyticusS. aureus Polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positive staphylococcus bacteria, such as and to coagulase-negative bacteria, such as and , are provided which can recognize surface proteins from both coagulase-positive and coagulase negative staph bacteria. The antibodies may be generated from surface proteins that have been isolated on the basis of characteristics that may be common between and coagulase-negative staphylococci, and these recombinant surface proteins are used to generate the antibodies of the invention. There is also provided vaccines and methods which utilize these proteins and antibodies for the treatment or protection against a wide variety of staphylococcal infections.
Author Patti, Joseph M
Foster, Timothy
Hutchins, Jeff T
Roche, Fiona
Pallen, Mark
Speziale, Pietro
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Universita'degli Studi di Pavia
The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin
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References Hook et al. (5320951) 19940600
Hook et al. (5440014) 19950800
Cabilly et al. (6331415) 20011200
Foster et al., "Clumper factor B (ClfB), a new surface-located fibrinogen-binding adhesion of Staplylococcus aureus", EMBL-GenBank Submission, Aug. 3, 1998.
Nilsson et al., "A Fibrinogen-Binding Protein of Staphylococcus epidermidis", Infection and Immunity, Jun. 1998, pp. 2666-2673.
McCrea et al., "The serine-aspartate repeat (Sdr) protein family in Staphylococcus epidemidis", Microbiology (2000), 146, pp. 1535-1546.
Hook et al. (5571514) 19961100
McDevitt et al., "Molecular characterization of the clumping factor (fibrinogen receptor) of Staphylococcus aureus", Molecular Microbiology, 1994, 11(2) pp. 237-248.
Brady, Jr. et al. (5707702) 19980100
Hook et al. (5652217) 19970700
McCrea et al., "A Family of Putative Adherence Proteins Related to the Clumping Factor of Staphylococcus aureus", Abstracts of the General Meeting of the American Society for Microbiology (1998), vol. 98, p. 63.
Hook et al. (5789549) 19980800
(WO 0071585) 20001100
Mazmanian et al., "Sortase-catalysed anchoring of surface proteins to the cell wall of Staphylococcus aureus", MicroReview, Molecular Microbiology (2001), 40(5), 1049-1057.
Hook et al. (6288214) 20010900
Foster et al. (6008341) 19991200
(0 519 596) 19921200
Kuroda et al. The Lancet. Apr. 2001. 357(9264):1225-1240.
Cockayne et al., "Molecular Cloning of a 32-Kilodalton Lipoprotein Component of a Novel Iron-Regulated . . . ", Infection and Immunity, Aug. 1998, pp. 3767-3774.
Cabilly et al. (4816567) 19890300
Hook et al. (5840846) 19981100
Hook et al. (5980908) 19991100
Fattom (6294177) 20010900
Morrison et al. (5807715) 19980900
Kenten et al. (5981216) 19991100
Foster et al. (6177084) 20010100
(WO 0012689) 20000300
Guss et al. (5851794) 19981200
Hook et al. (5175096) 19921200
Hook et al. (6086895) 20000700
(WO 9748727) 19971200
Hook et al. (5416021) 19950500
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Title Cross-reactive monoclonal and polyclonal antibodies which recognize surface proteins from coagulase-negative staphylococci and Staphylococcus aureus
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