Peptides having antiangiogenic activity
The invention relates to novel compounds having activity useful for treating conditions which arise or are exacerbated by angiogenesis, pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, and methods of inhibiting angiogenesis. Peptides of formula (I)are u...
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Main Authors | , , , , |
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Format | Patent |
Language | English |
Published |
22.06.2004
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Abstract | The invention relates to novel compounds having activity useful for treating conditions which arise or are exacerbated by angiogenesis, pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, and methods of inhibiting angiogenesis.
Peptides of formula (I)are useful for inhibiting angiogenesis. Also disclosed are angiogenesis-inhibiting compositions and methods of inhibiting angiogenesis in a mammal. |
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AbstractList | The invention relates to novel compounds having activity useful for treating conditions which arise or are exacerbated by angiogenesis, pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, and methods of inhibiting angiogenesis.
Peptides of formula (I)are useful for inhibiting angiogenesis. Also disclosed are angiogenesis-inhibiting compositions and methods of inhibiting angiogenesis in a mammal. |
Author | Kalvin, Douglas M Bradley, Michael F Haviv, Fortuna Henkin, Jack Schneider, Andrew J |
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References | Folkman, et al., Science, vol. 235, 1987, pp. 442-447. Majack, et al., Cell Membranes Methods-Reviews, vol. 3, 1987, pp. 55-77. Donoviel, et al., J. Biological Chemistry, vol. 263 (35), 1988, pp. 18590-18593. (98 41542) 19980900 Tolsma, et al., J. Cell Biol., vol. 122 (2), 1993, pp. 497-511. Deutch et al. (5426100) 19950600 Deutch et al. (5190918) 19930300 Gasparini, et al., J. Clinical Oncology, vol. 13 (3), 1995, pp. 765-782. Haverstick, et al., Biochemistry, vol. 23, 1984, pp. 5597-5603. (93 16716) 19930900 U.S. patent applicatiion Ser. No. 60/166,791, filed Nov. 22, 1999. Folkman, et al., The Journal of Biological Chemistry, vol. 264 (12), 1989, pp. 6892-6897. Hennessy, et al., J. Cell Biology, vol. 108, 1989, pp. 729-736. Folkman, Cancer Research, vol. 46, 1986, pp. 467-473. Deutch et al. (5200397) 19930400 Bouck et al. (5192744) 19930300 Prescott, Ed., Methods in Cell Biology, vol. XIV, Academic Press, New York, N.Y., 1976, pp. 33 et seq. U.S. patent application Ser. No. 09/316,888, filed May 21, 1999. Folkman, Journal of the National Cancer Institute, vol. 82 (1), 1990, pp. 4-6. (0 443 404) 19910800 Santoro, et al., Methods in Enzymology, vol. 144, 1987, pp. 438-446. (97 41824) 19971100 Weidner, et al., The New England Journal of Medicine, vol. 324 (1), 1991, pp. 1-8. Lawler, et al., J. Cell Biology, vol. 103, 1986, pp. 1635-1648. |
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