Microparticles
The present invention lies within the field of galenic formulations for the administration of biologically active substances, more precisely microparticles for controlled release intended for parenteral administration of biologically active substances, especially drugs. More specifically, it relates...
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| Main Authors | , , , |
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| Format | Patent |
| Language | English |
| Published |
16.03.2004
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| Online Access | Get full text |
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| Summary: | The present invention lies within the field of galenic formulations for the administration of biologically active substances, more precisely microparticles for controlled release intended for parenteral administration of biologically active substances, especially drugs. More specifically, it relates to a novel production process for such particles containing a biologically active substance and to novel particles for controlled release obtainable thereby.
A process for producing parenterally administrable microparticles, in which an at least 20% by weight aqueous solution of purified amylopectin-based starch of reduced molecular weight is prepared, the solution is combined with biologically active substance, an emulsion of starch droplets is formed in an outer phase of polymer solution, the starch droplets are made to gel, and the gelled starch particles are dried. A release-controlling shell is optionally also applied to the particles.Microparticles which essentially consist of said starch, have an amino acid content of less than 50 g and have no covalent chemical cross-linking. |
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