2-arachidonylglycerol (2-AG)-an inhibitor of tumor necrosis factor- and neuroprotector of brain in closed head injury
1. The present invention relates to 2-arachidonylglycerol (2-AG) to be used as inhibitor of a tumor necrosis factor (TNF- ), in the reduction of edema caused by closed head injury, in the reduction of neurological deficits caused by closed head injury and stroke and in treating pathological conditio...
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| Format | Patent |
| Language | English |
| Published |
20.05.2003
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| Online Access | Get full text |
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| Abstract | 1. The present invention relates to 2-arachidonylglycerol (2-AG) to be used as inhibitor of a tumor necrosis factor (TNF- ), in the reduction of edema caused by closed head injury, in the reduction of neurological deficits caused by closed head injury and stroke and in treating pathological conditions caused by TNF- and/or by radical oxgen intermediates (ROI), in pharmaceutical composition for the same use comprising as active ingredient 2-AG, the use of 2-AG and pharmaceutical compositions comprising same in the preparation of a medicament for the treatment of said indications and methods of treatment by 2-AG and pharmaceutical compositions comprising same for diseases caused by said indications.
The present invention relates to 2-arachidonylglycerol (2-AG) to be used as inhibitor of a tumor necrosis factor (TNF- ), in the reduction of edema caused by closed head injury, in the reduction of neurological deficits caused by closed head injury and stroke and in treating pathological conditions caused by TNF- and/or by radical oxygen intermediates (ROI), in pharmaceutical composition for the same use comprising as active ingredient 2-AG. It comprises also the use of 2-AG and pharmaceutical compositions comprising same in the preparation of a medicament for the treatment of said indications and methods of treatment by 2-AG and pharmaceutical compositions comprising same for diseases caused by said indications. |
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| AbstractList | 1. The present invention relates to 2-arachidonylglycerol (2-AG) to be used as inhibitor of a tumor necrosis factor (TNF- ), in the reduction of edema caused by closed head injury, in the reduction of neurological deficits caused by closed head injury and stroke and in treating pathological conditions caused by TNF- and/or by radical oxgen intermediates (ROI), in pharmaceutical composition for the same use comprising as active ingredient 2-AG, the use of 2-AG and pharmaceutical compositions comprising same in the preparation of a medicament for the treatment of said indications and methods of treatment by 2-AG and pharmaceutical compositions comprising same for diseases caused by said indications.
The present invention relates to 2-arachidonylglycerol (2-AG) to be used as inhibitor of a tumor necrosis factor (TNF- ), in the reduction of edema caused by closed head injury, in the reduction of neurological deficits caused by closed head injury and stroke and in treating pathological conditions caused by TNF- and/or by radical oxygen intermediates (ROI), in pharmaceutical composition for the same use comprising as active ingredient 2-AG. It comprises also the use of 2-AG and pharmaceutical compositions comprising same in the preparation of a medicament for the treatment of said indications and methods of treatment by 2-AG and pharmaceutical compositions comprising same for diseases caused by said indications. |
| Author | Panikashvili, David Breuer, Aviva Gallily, Ruth Shohami, Esther Mechoulam, Raphael |
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| References | (0505817) 19920900 (9951560) 19991000 German et al. (5456912) 19951000 Di Marzo, V. et al: Cannabimimetic Fatty Acid Derivatives in Cancer and Inflammation; Prostaglandins and Other Lipid Mediators, vol. 61, Nos. 1-2, pp. 43-61, XP004197447. Sinor, A.D. et al.: "Endocannabinoids Protect Cerebral Cortical Neurons From In Vitro Ischemia in Rats"; Neuroscience Letters, vol. 278, No. 3, Jan. 14, 2000; pp. 157-160, XP002205898. |
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| Snippet | 1. The present invention relates to 2-arachidonylglycerol (2-AG) to be used as inhibitor of a tumor necrosis factor (TNF- ), in the reduction of edema caused... |
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| Title | 2-arachidonylglycerol (2-AG)-an inhibitor of tumor necrosis factor- and neuroprotector of brain in closed head injury |
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