Polybifunctional reagent having a polymeric backbone and latent reactive moieties and bioactive groups

In one aspect, this invention relates to reagents that can be used to modify biomaterial surfaces or to fabricate new biomaterials. In another aspect, the invention relates to biomaterials having surfaces that have been prepared or modified to provide desired bioactive function. A polybifunctional r...

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Main Authors Clapper, David L, Swanson, Melvin J, Hu, Sheau-Ping, Amos, Richard A, Everson, Terrence P
Format Patent
LanguageEnglish
Published 04.02.2003
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Abstract In one aspect, this invention relates to reagents that can be used to modify biomaterial surfaces or to fabricate new biomaterials. In another aspect, the invention relates to biomaterials having surfaces that have been prepared or modified to provide desired bioactive function. A polybifunctional reagent is provided having a polymeric backbone, one or more pendent latent reactive (preferably photoreactive) moieties, and two or more pendent bioactive groups. The reagent can be activated to form a bulk material or can be brought into contact with the surface of a previously formed biomaterial and activated to form a coating. The pendent bioactive groups function by promoting the attachment of specific molecules or cells to the bulk material or coated surface. Bioactive groups can include proteins, peptides, carbohydrates, nucleic acids and other molecules that are capable of binding noncovalently to specific and complimentary portions of molecules or cells.
AbstractList In one aspect, this invention relates to reagents that can be used to modify biomaterial surfaces or to fabricate new biomaterials. In another aspect, the invention relates to biomaterials having surfaces that have been prepared or modified to provide desired bioactive function. A polybifunctional reagent is provided having a polymeric backbone, one or more pendent latent reactive (preferably photoreactive) moieties, and two or more pendent bioactive groups. The reagent can be activated to form a bulk material or can be brought into contact with the surface of a previously formed biomaterial and activated to form a coating. The pendent bioactive groups function by promoting the attachment of specific molecules or cells to the bulk material or coated surface. Bioactive groups can include proteins, peptides, carbohydrates, nucleic acids and other molecules that are capable of binding noncovalently to specific and complimentary portions of molecules or cells.
Author Clapper, David L
Everson, Terrence P
Hu, Sheau-Ping
Amos, Richard A
Swanson, Melvin J
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