Interleukin-1 converting enzyme like cysteine protease

The invention relates to a novel cysteine protease having homology to interleukin-1 converting enzyme (ICE). The protease represents a member of a family of cysteine proteases termed LICE (Like ICE) which may be involved in modulating apoptosis. A new member of a family of ICE-like cysteine protease...

Full description

Saved in:
Bibliographic Details
Main Authors Juan, Shao-Chieh, Fletcher, Frederick A, Patterson, Scott D
Format Patent
LanguageEnglish
Published 28.01.2003
Online AccessGet full text

Cover

More Information
Summary:The invention relates to a novel cysteine protease having homology to interleukin-1 converting enzyme (ICE). The protease represents a member of a family of cysteine proteases termed LICE (Like ICE) which may be involved in modulating apoptosis. A new member of a family of ICE-like cysteine proteases has been identified. The protease family is termed LICE (Like ICE) and the family member described herein is LICE3. LICE3 polypeptides, nucleic acids encoding LICE3 and vectors and host cells for the expression LICE3 are disclosed. Also disclosed are methods for identifying LICE3 agonists and antagonists, and methods for treatment of disorders characterized by altered apoptosis.