Oral transmucosal delivery

The present invention relates to an autoadhesive oral transmucosal delivery device for delivering a pharmaceutically active agent via mucosal tissues in the mouth. The invention also relates to the use of a hydrogel body in preparation of a medicament for oral transmucosal delivery. An autoadhesive...

Full description

Saved in:
Bibliographic Details
Main Authors Halliday, Janet Anne, Robertson, Steven
Format Patent
LanguageEnglish
Published 03.12.2002
Online AccessGet full text

Cover

Abstract The present invention relates to an autoadhesive oral transmucosal delivery device for delivering a pharmaceutically active agent via mucosal tissues in the mouth. The invention also relates to the use of a hydrogel body in preparation of a medicament for oral transmucosal delivery. An autoadhesive oral transmucosal delivery device contains a pharmaceutically active agent which is delivered via mucosal tissues in the mouth. The device comprises a dry hydrogel polymer which autoadheres to the moist mucosal surface for a time sufficient for release of active agent to occur before becoming detached.
AbstractList The present invention relates to an autoadhesive oral transmucosal delivery device for delivering a pharmaceutically active agent via mucosal tissues in the mouth. The invention also relates to the use of a hydrogel body in preparation of a medicament for oral transmucosal delivery. An autoadhesive oral transmucosal delivery device contains a pharmaceutically active agent which is delivered via mucosal tissues in the mouth. The device comprises a dry hydrogel polymer which autoadheres to the moist mucosal surface for a time sufficient for release of active agent to occur before becoming detached.
Author Robertson, Steven
Halliday, Janet Anne
Author_xml – sequence: 1
  fullname: Halliday, Janet Anne
– sequence: 2
  fullname: Robertson, Steven
BookMark eNrjYmDJy89L5WSQ8i9KzFEoKUrMK84tTc4vBnJSUnMyy1KLKnkYWNMSc4pTeaE0N4OCm2uIs4duaXFBYklqXklxfDpQH5AyMDOxsLA0NTYmQgkAHTsmEQ
ContentType Patent
CorporateAuthor Controlled Therapeutics (Scotland) Ltd
CorporateAuthor_xml – name: Controlled Therapeutics (Scotland) Ltd
DBID EFH
DatabaseName USPTO Issued Patents
DatabaseTitleList
Database_xml – sequence: 1
  dbid: EFH
  name: USPTO Issued Patents
  url: http://www.uspto.gov/patft/index.html
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
ExternalDocumentID 06488953
GroupedDBID EFH
ID FETCH-uspatents_grants_064889533
IEDL.DBID EFH
IngestDate Sun Mar 05 22:42:46 EST 2023
IsOpenAccess true
IsPeerReviewed false
IsScholarly false
Language English
LinkModel DirectLink
MergedId FETCHMERGED-uspatents_grants_064889533
OpenAccessLink https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6488953
ParticipantIDs uspatents_grants_06488953
PatentNumber 6488953
PublicationCentury 2000
PublicationDate 20021203
PublicationDateYYYYMMDD 2002-12-03
PublicationDate_xml – month: 12
  year: 2002
  text: 20021203
  day: 03
PublicationDecade 2000
PublicationYear 2002
References Robinson (4615697) 19861000
Ch'ng, H.S. et al., "Bioadhesive Polymers as Platforms for Oral Controlled Drug Delivery II: Synthesis and Evaluation of Some Swelling, Water-Insoluble Bioadhesive Polymers", Journal of Pharmaceutical Sciences, vol. 74, No. 4: 399-405 (1985).
Benes et al. (5639469) 19970600
Acharya (5661171) 19970800
El-Rashidy et al. (5624667) 19970400
Acharya (5686094) 19971100
Acharya (5731338) 19980300
Park, H. et al., "Physico-Chemical Properties of Water Insoluble Polymers Important to Mucin/Epithelial Adhesion", Journal of Controlled Release, 2: 47-57 (1985).
Landrau et al. (5512293) 19960400
3M Pharmaceuticals, "3M Cydot Trunsmucosal Delivery System", Brochure: 1-8, 1995 (unconfirmed).
(2 047 094) 19801100
Lee et al. (5571528) 19961100
(2 047 093) 19831200
Tiwari, D. et al., "Evaluation of Polyoxyethylene Homopolymers for Buccal Bioadhesive Drug Delivery Device Formulations", PharmSci, Sep. 15, 1999; 1(3): 1-8, http://pharmsci.org/journal.
Mcquinn (5113860) 19920500
Acharya (5741805) 19980400
(2 047 094) 19831200
Park, H. et al., "Mechanisms of Mucoadhesion of Poly (acrylic Acid) Hydrogels", Pharmaceutical Research, vol. 4, No. 6: 457-464 (1987).
Peppas, N.A., et al., "Hydrogels as mucoadhesive and bioadhesive materials: a review", Biomaterials 17: 1553-1561 (1983).
References_xml – year: 19970600
  ident: 5639469
  contributor:
    fullname: Benes et al.
– year: 19831200
  ident: 2 047 093
– year: 19971100
  ident: 5686094
  contributor:
    fullname: Acharya
– year: 19980300
  ident: 5731338
  contributor:
    fullname: Acharya
– year: 19831200
  ident: 2 047 094
– year: 19970400
  ident: 5624667
  contributor:
    fullname: El-Rashidy et al.
– year: 19980400
  ident: 5741805
  contributor:
    fullname: Acharya
– year: 19961100
  ident: 5571528
  contributor:
    fullname: Lee et al.
– year: 19801100
  ident: 2 047 094
– year: 19861000
  ident: 4615697
  contributor:
    fullname: Robinson
– year: 19960400
  ident: 5512293
  contributor:
    fullname: Landrau et al.
– year: 19920500
  ident: 5113860
  contributor:
    fullname: Mcquinn
– year: 19970800
  ident: 5661171
  contributor:
    fullname: Acharya
Score 2.5604606
Snippet The present invention relates to an autoadhesive oral transmucosal delivery device for delivering a pharmaceutically active agent via mucosal tissues in the...
SourceID uspatents
SourceType Open Access Repository
Title Oral transmucosal delivery
URI https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6488953
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwY2BQMTc3NTU2MzbWTTNIM9M1MU6z0E00NTTTNU01NTc2MjdLTrIEbXD29TPzCDXxijCNYGLwgO-FyQVmI90CoFuK9UqLC0rywYsrgcU7JOJ1IYc_g84IzAOdPlCel5OfmBKQkqZvBkyJlqbGzAzMFgagpX2ubh7cDJxAI4BNtrySYqRKw02QgS0ALCrEwJSaJ8Ig5V-UmKNQAqobckHLxIGclNQc0LKISlEGBTfXEGcPXbhB8elFoAUq8QZQC43FGFiAHfVUCQYFY2BBn5xkDqxgk01MUg3NLAzMgO0b8zQLUDZJMzaQZJDEaYwUHjlpBi7YHSQGxjIMLCVFpamywKqwJEkO7E8AudBncQ
link.rule.ids 230,309,783,805,888,64374
linkProvider USPTO
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV07T8MwED6VgnhMIEBteWVgNbhcbKczNAqvkgGkblEeNkuaVokrxL_nnELFAqNt6WzLvvvO8ufPAJdKCYESkRluJPPRBCwVQ8mEFgpvlMyzkXvg_DyR0Zv_MBXTDkTrtzAzciO2oLE0V8tmYectuZLC-2rh2Ur82WkEVk594KMq52kRF-Za0k4cCdyATXcV5VT0x2G0BztkhJK2yja_YCPch624rT2Ajq4OYfBSp6VnHTrMHFGcCoUuHTHi8wi8cPx6G7G1oeS9dhSVhH93icfQpaO67oGHFOrzTBHE5r6vhzLgkjIcZQLnKAZ5H_p_mhn803YB2_FdmDzdTx5PYPfnQxKOp9C19VKfES7a7Lyd8hf9q2ps
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=Oral+transmucosal+delivery&rft.inventor=Halliday%2C+Janet+Anne&rft.inventor=Robertson%2C+Steven&rft.number=6488953&rft.date=2002-12-03&rft.externalDBID=n%2Fa&rft.externalDocID=06488953