Bicyclic fibrinogen antagonists

This invention relates to novel bicyclic compounds which inhibit platelet aggregation, pharmaceutical compositions containing the compounds and methods of using the compounds. This invention relates to compounds of the formulae: whereinAis O, S, N-Ror CHR;Ais N-Ror CHR;Ris a sidechain containing an...

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Bibliographic Details
Main Authors Bondinell, William Edward, Callahan, James Francis, Huffman, William Francis, Keenan, Richard McCulloch, Ku, Thomas Wen-Fu, Newlander, Kenneth Allen, Samanen, James Martin, Uzinskas, Irene Nijole
Format Patent
LanguageEnglish
Published 11.06.2002
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Summary:This invention relates to novel bicyclic compounds which inhibit platelet aggregation, pharmaceutical compositions containing the compounds and methods of using the compounds. This invention relates to compounds of the formulae: whereinAis O, S, N-Ror CHR;Ais N-Ror CHR;Ris a sidechain containing an acid or ester group;R, Rand Rare substituents such as H, alkyl and aryl alkyl, andRis a sidechain containing a nitrogen group; andpharmaceutically acceptable salts thereof,which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, and a method for inhibiting platelet aggregation.