Process for the enzymatic resolution of lactams

• Main Authors: Hansen, Donald, Trivedi, Mahima, Gapud, Rolando, Ng, John, Awasthi, Alok, Wang, Ping
• Format: Patent
• Language: English
• Published: 27.12.2001

A method of separating enantiomeric lactam esters. The lactam esters are contacted with a biocatalyst, such as an enzyme or a microorganism, in a solution wherein only one enantiomer is selectively hydrolyzed to give the optically active isomer of the corresponding acid. The hydrolysis product is th...