A METHOD FOR DIAGNOSING A DISEASE BY DETECTION OF circRNA IN BODILY FLUIDS

The present application relates to a method for diagnosing a disease of a subject, comprising the step of determining the presence or absence of one or more circular RNA (circRNA) in a sample of a bodily fluid of said subject; wherein the presence or absence of said one or more circRNA is indicative...

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Format Patent
LanguageEnglish
Published 29.09.2016
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Summary:The present application relates to a method for diagnosing a disease of a subject, comprising the step of determining the presence or absence of one or more circular RNA (circRNA) in a sample of a bodily fluid of said subject; wherein the presence or absence of said one or more circRNA is indicative for the disease. In particular the application relates to a method for diagnosing the neurodegenerative disease, preferably Alzheimer's disease, in a subject comprises the steps of -determining the level of one or more circRNA in a sample of a bodily fluid of said subject; -comparing the determined level to a control level of said one or more circRNA; wherein differing levels between the determined and the control level are indicative for the disease. Furthermore, the application relates to means for detecting circRNAs being a biomarker for a neurodegenerative disease and kits and array comprising nucleic acid probes for detecting exon-exon junctions in a head to tail arrangement of these circRNAs.