TREATING VARIOUS DISORDERS WITH 7,8-DIHYDROXYFLAVONE AND DERIVATIVES THEREOF
Novel compounds and methods related to the activation of the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of 7,8-dihydroxyflavone or derivative thereof. Specifically, methods and compounds for the treatment of disorders includin...
Saved in:
| Format | Patent |
|---|---|
| Language | English |
| Published |
23.07.2009
|
| Online Access | Get full text |
Cover
| Abstract | Novel compounds and methods related to the activation of the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of 7,8-dihydroxyflavone or derivative thereof. Specifically, methods and compounds for the treatment of disorders including neurologic disorders, neuropsychiatric disorders, and metabolic disorders (e.g., obesity) are provided. For example, a first method is provided of treating or reducing the risk of depression, anxiety, or obesity in a subject, which includes selecting a subject with or at risk of developing depression, anxiety, or obesity, and administering to the subject a therapeutically effective amount of 7,8-dihydroxyflavone or a derivative thereof. A further method of promoting neuroprotection in a subject also is provided, which includes selecting a subject in need of neuroprotection, and administering to the subject a therapeutically effective amount of 7,8-dihydroxyflavone or a derivative thereof. |
|---|---|
| AbstractList | Novel compounds and methods related to the activation of the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of 7,8-dihydroxyflavone or derivative thereof. Specifically, methods and compounds for the treatment of disorders including neurologic disorders, neuropsychiatric disorders, and metabolic disorders (e.g., obesity) are provided. For example, a first method is provided of treating or reducing the risk of depression, anxiety, or obesity in a subject, which includes selecting a subject with or at risk of developing depression, anxiety, or obesity, and administering to the subject a therapeutically effective amount of 7,8-dihydroxyflavone or a derivative thereof. A further method of promoting neuroprotection in a subject also is provided, which includes selecting a subject in need of neuroprotection, and administering to the subject a therapeutically effective amount of 7,8-dihydroxyflavone or a derivative thereof. |
| BookMark | eNrjYmDJy89L5WTwCQlydQzx9HNXCHMM8vQPDVZw8Qz2D3JxDQpWCPcM8VAw17HQdfH0iHQJ8o-IdPNxDPP3c1Vw9HNRACrxDANqDXMNVgjxcA1y9XfjYWBNS8wpTuWF0twMam6uIc4euqXFBYklqXklxfGJBQU5mcmJJZn5ecXxhsYGpqYWZobGRCsEAHNSNeQ |
| ContentType | Patent |
| CorporateAuthor | EMORY UNIVERSITY |
| CorporateAuthor_xml | – name: EMORY UNIVERSITY |
| DBID | EFI |
| DatabaseName | USPTO Published Applications |
| DatabaseTitleList | |
| Database_xml | – sequence: 1 dbid: EFI name: USPTO Published Applications url: http://www.uspto.gov/patft/index.html sourceTypes: Open Access Repository |
| DeliveryMethod | fulltext_linktorsrc |
| ExternalDocumentID | 20110144196 |
| GroupedDBID | EFI |
| ID | FETCH-uspatents_applications_130558613 |
| IEDL.DBID | EFI |
| IngestDate | Sun Mar 05 22:45:22 EST 2023 |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | false |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-uspatents_applications_130558613 |
| OpenAccessLink | https://patentcenter.uspto.gov/applications/13055861 |
| ParticipantIDs | uspatents_applications_13055861 |
| PublicationCentury | 2000 |
| PublicationDate | 20090723 |
| PublicationDateYYYYMMDD | 2009-07-23 |
| PublicationDate_xml | – month: 07 year: 2009 text: 20090723 day: 23 |
| PublicationDecade | 2000 |
| PublicationYear | 2009 |
| Score | 2.690958 |
| Snippet | Novel compounds and methods related to the activation of the TrkB receptor are provided. The methods include administering in vivo or in vitro a... |
| SourceID | uspatents |
| SourceType | Open Access Repository |
| Title | TREATING VARIOUS DISORDERS WITH 7,8-DIHYDROXYFLAVONE AND DERIVATIVES THEREOF |
| URI | https://patentcenter.uspto.gov/applications/13055861 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhVxNT8MwDLVgQgJOIEB8DMgBcSII-p1jRVMaNLWo7Up3mpo2PW7T1v1_nA7QOO1qPSdWJMt5sp8BHmqzaW3DNmntMo9aZlVRqZhLq4ZJp_UaiSY9bRE70dj6KO3yRxSmtTAL_GHNOj2YqJbP69Wim_fTlf-6ua96S5WnOc--5-h9-TwUx3CI6N55tVUgwhM4-Oytp7CnZmcwylPu5yJ-J4WfimSckUBkSLd4mpEvkUfEffJoIKJJkCblJBz5RRJz4scBQYgo0LXgGckjnvIkPIfHkOdvEf27erod6PQ3UPMCBkjm1SUQZrwwo261dAJJKWtk3VhuiySkrTEdlH0F9zsOu96JuIGjTc_DpYY5hEG3XKtbLJ2dvOvf6ht7aXRD |
| linkProvider | USPTO |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhVzNT4MwFH_Rafw4adT4vR6MJ6sGxqBHIkWqBBZguJ0WoHBStgiL_76vzJjddm1eX5v2vf76y_sAuCt0WRmaodPCZBYd6FlG85KZNJMsH1aWzHFIZVsEQ288eJsYk7_y6K4W5gvdiC5wL83jslm08y65Ep_31cXTVfNn1SOwVt0HfurPeSZHsnrqgEyxAzbchh20Kl3ZO3fFIeyjIvy41W2zBh3uEeyOutFj2CrrE_CTiNuJCF5JakciHMfEETESMR7F5EMkHjEfLOoIb-pE4WTq-nYaBpzYgUNQRKQ4NeUxSTwe8dA9hXuXJy8e_V96th6QVkEkw7AQSs-ghzS_PAfCtGemFZUqqkC6ymReyIFZIT2pCnSU0riA_gZllxsl-rA3ctyZL4L3KzhYBUZMqunX0Gu_l-UN4mub33bH9gtjyn-H |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=TREATING+VARIOUS+DISORDERS+WITH+7%2C8-DIHYDROXYFLAVONE+AND+DERIVATIVES+THEREOF&rft.date=2009-07-23&rft.externalDBID=n%2Fa&rft.externalDocID=20110144196 |