Prostate Cancer Glycan Markers and Autoantibody Signatures

• Format: Patent
• Language: English
• Published: 10.04.2009

Euonymus europaeus Psophocarpus Tetragonolobus Griffonia Simplicifolia Griffonia Simplicifolia Sambucus nigra Phaseolus vulgarisGalanthus nivalis Narcissus pseudonarcissus Artocarpus integrifolia Disclosed are methods for probing the immunogenic sugar moieties of prostate cancer cells. The methods detect a number of glyco-epitopes that are highly and differentially expressed among prostate cancers of various Gleason grades. The glyco-epitopes exist on the surfaces of prostate cells. The methods also comprise the detection of autoantibodies in prostate cancer subjects. The antibodies bound to a glyco-motif of N-glycans that is normally "cryptic." This target is highly expressed in prostate cancers. Lectins and antibodies that detect these glyco-epitopes that expressed in prostate cancer tissues include lectin (EEL); Lectin-I (PTL-I); Lectin-I-A (GSL-I-A); Lectin-I-B (GSL-I-B); I agglutinin (SNA-I; -L (PHA-L; agglutinin (GNA); agglutinin (NPA); agglutinin (Jacalin); and mAb TM (IgM).