Vacunas y autoinmunidad: una rara asociación bajo debate
La posible asociación entre vacunas y enfermedades autoinmunes es un tema controversial. Existen elementos a favor de esta relación basados en modelos teóricos, ensayos de laboratorio y varios casos clínicos publicados. En cambio, los estudios epidemiológicos no han confirmado esta asociación y, de...
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| Published in | Revista peruana de medicina experimental y salud pública Vol. 29; no. 2; pp. 265 - 271 |
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| Main Author | |
| Format | Journal Article |
| Language | Portuguese |
| Published |
Instituto Nacional de Salud
01.06.2012
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| Abstract | La posible asociación entre vacunas y enfermedades autoinmunes es un tema controversial. Existen elementos a favor de esta relación basados en modelos teóricos, ensayos de laboratorio y varios casos clínicos publicados. En cambio, los estudios epidemiológicos no han confirmado esta asociación y, de ellos, puede inferirse que las vacunas no constituyen una causa demostrada de enfermedades autoinmunes. En este trabajo se analizan las evidencias a favor y en contra de esta controversial asociación, además, se aborda un nuevo síndrome asociado con la administración continuada de adyuvantes vacunales. Se concluye que debido al gran impacto en beneficio de la salud logrado con las vacunas, es necesario continuar desarrollando esta tecnología, pero también se debe seguir perfeccionando los diseños de las nuevas formulaciones y profundizando estudios básicos, preclínicos, ensayos clínicos y farmacovigilancia de los nuevos candidatos vacunales para establecer el riesgo real de desarrollo de un evento autoinmune posvacunación. |
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| AbstractList | La posible asociación entre vacunas y enfermedades autoinmunes es un tema controversial. Existen elementos a favor de esta relación basados en modelos teóricos, ensayos de laboratorio y varios casos clínicos publicados. En cambio, los estudios epidemiológicos no han confirmado esta asociación y, de ellos, puede inferirse que las vacunas no constituyen una causa demostrada de enfermedades autoinmunes. En este trabajo se analizan las evidencias a favor y en contra de esta controversial asociación, además, se aborda un nuevo síndrome asociado con la administración continuada de adyuvantes vacunales. Se concluye que debido al gran impacto en beneficio de la salud logrado con las vacunas, es necesario continuar desarrollando esta tecnología, pero también se debe seguir perfeccionando los diseños de las nuevas formulaciones y profundizando estudios básicos, preclínicos, ensayos clínicos y farmacovigilancia de los nuevos candidatos vacunales para establecer el riesgo real de desarrollo de un evento autoinmune posvacunación. |
| Author | Batista-Duharte, Alexander |
| AuthorAffiliation | Universidad de Ciencias Médicas |
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| DocumentTitleAlternate | Vaccines and autoimmunity: a strange association under debate |
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| Keywords | Autoimmunity Vacunas Vaccines Adjuvants, immunologic Autoimmune diseases Enfermedad autoinmunes Adyuvantes inmunitarios Autoinmunidad |
| Language | Portuguese |
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The occurrence, pathogenesis and significance of autoimmune manifestations after viral vaccines publication-title: Vaccine contributor: fullname: Schattner, A – volume: 41 start-page: 58 issue: 1 year: 1998 end-page: 67 article-title: Prevalence of spondyloarthropathies in HLA-B27 positive and negative blood donors publication-title: Arthritis Rheum contributor: fullname: Braun, J; Bollow, M; Remlinger, G; Eggens, U; Rudwaleit, M; Distler, A – volume: 14 start-page: 86 issue: 2 year: 2004 end-page: 90 article-title: Autoimmune diseases and vaccinations publication-title: Eur J Dermatol contributor: fullname: Vial, T; Descotes, J – volume: 107 start-page: 116 issue: 2 year: 2003 end-page: 21 article-title: Influenza vaccination and Guillain Barre syndrome small star, filled publication-title: Clin Immunol contributor: fullname: Geier, MR; Geier, DA; Zahalsky, AC – volume: 20 start-page: 119 issue: 1 year: 2002 article-title: Hepatitis B vaccination and arthritic adverse reactions: a follow-up analysis of the Vaccine Adverse Events Reporting System (VAERS) database publication-title: Clin Exp Rheumatol contributor: fullname: Geier, DA; Geier, MR – start-page: 261 issue: 6 year: 2007 end-page: 6 article-title: Vaccination, infection and autoimmunity: myth and reality VIAMR 2005-10-26- 28, Beau-Rivage Palace Hotel, Lausanne, Switzerland publication-title: Autoimmunity Rev contributor: fullname: Orbach, H; Shoenfeld, Y – volume: 17 start-page: 91 issue: 3 year: 1997 end-page: 9 article-title: Animal models of autoimmune diseases publication-title: Rheumatol Int contributor: fullname: Burkhardt, H; Kalden, JR – volume: 337 start-page: 1183 issue: 8751 year: 1991 end-page: 7 article-title: Identification of hepatitis A virus as a trigger for autoimmune chronic hepatitis type 1 in susceptible individuals publication-title: Lancet contributor: fullname: Vento, S; Garofano, T; Di Perri, G; Dolci, L; Concia, E; Bassetti, D – volume: 4 start-page: 12 issue: 1 year: 2003 end-page: 21 article-title: Autoimmune regulator: from loss of function to autoimmunity publication-title: Genes Immun contributor: fullname: Pitkanen, J; Peterson, P – volume: 21 start-page: 308 issue: 3 year: 2009 end-page: 13 article-title: Yellow fever vaccine - how does it work and why do rare cases of serious adverse events take place? publication-title: Curr Opin Immunol contributor: fullname: Barrett, AD; Teuwen, DE – volume: 203 start-page: 97 issue: 2 year: 2011 end-page: 105 article-title: Progress in understanding adjuvant immunotoxicity mechanisms publication-title: Toxicol Lett contributor: fullname: Batista-Duharte, A; Lindblad, EB; Oviedo-Orta, E – volume: 154 start-page: 205 issue: 3 year: 1998 end-page: 7 article-title: Sclerotic plaques and vaccination against hepatitis B publication-title: Rev Neurol (Paris) contributor: fullname: Gout, O; Lyon-Caen, O – volume: 292 start-page: 2478 issue: 20 year: 2004 end-page: 81 article-title: Guillain-Barré syndrome following influenza vaccination publication-title: JAMA contributor: fullname: Haber, P; DeStefano, F; Angulo, FJ; Iskander, J; Shadomy, SV; Weintraub, E – volume: 318 start-page: 1169 issue: 7192 year: 1999 end-page: 72 article-title: Association between type 1 diabetes and Haemophilus influenzae type b vaccination: birth cohort study publication-title: BMJ contributor: fullname: Karvonen, M; Cepaitis, Z; Tuomilehto, J – volume: 36 start-page: 4 issue: 1 year: 2011 end-page: 8 article-title: ‘ASIA’ - autoimmune/ inflammatory syndrome induced by adjuvants publication-title: J Autoimmun contributor: fullname: Shoenfeld, Y; Agmon-Levin, N – volume: 4 start-page: 96 issue: 2 year: 2005 end-page: 100 article-title: Autoimmune hazards of hepatitis B vaccine publication-title: Autoimmun Rev contributor: fullname: Girard, M – volume: 338 start-page: 1174 issue: 8776 year: 1991 end-page: 5 article-title: Central-nervoussystem demyelination after immunisation with recombinant hepatitis B vaccine publication-title: Lancet contributor: fullname: Herroelen, L; de Keyser, J; Ebinger, G – volume: 18 start-page: 217 issue: 3 year: 1999 end-page: 22 article-title: Childhood immunizations and type 1 diabetes: summary of an Institute for Vaccine Safety Workshop. 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| Title | Vacunas y autoinmunidad: una rara asociación bajo debate |
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