APOE4 Copy Number-Dependent Proteomic Changes in the Cerebrospinal Fluid 1

• Published in: Journal of Alzheimer's disease Vol. 79; no. 2; pp. 511 - 530
• Main Authors: Berger, Miles, Cooter, Mary, Roesler, Alexander S., Chung, Stacey, Park, John, Modliszewski, Jennifer L., VanDusen, Keith W., Thompson, J. Will, Moseley, Arthur, Devinney, Michael J., Smani, Shayan, Hall, Ashley, Cai, Victor, Browndyke, Jeffrey N., Lutz, Michael W., Corcoran, David L.
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 19.01.2021
• Subjects: complement activation; C-reactive protein; Alzheimer disease; cerebrospinal fluid; mass spectrometry; biomarker; apolipoprotein E4; neurogenic inflammation

Background: APOE4 has been hypothesized to increase Alzheimer’s disease risk by increasing neuroinflammation, though the specific neuroinflammatory pathways involved are unclear. Objective: Characterize cerebrospinal fluid (CSF) proteomic changes related to APOE4 copy number. Methods: We analyzed ta...