Borylation iridium catalysed C-H activation: a new concise route to duocarmycin derivatives

• Published in: Organic & biomolecular chemistry Vol. 22; no. 27; pp. 563 - 567
• Main Authors: Cominetti, Marco M. D, Goddard, Zoë R, Hood, Bethany R, Beekman, Andrew M, O'Connell, Maria A, Searcey, Mark
• Format: Journal Article
• Published: 10.07.2024

The synthesis of the ethyl ester analogue of the ultrapotent antitumour antibiotic seco-duocarmycin SA has been achieved in eleven linear steps from commercially available starting materials. The DSA alkylation subunit can be made in ten linear steps from the same precursor. The route involves C-H a...