Comparative -adenosyl--methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation

• Published in: Chemical communications (Cambridge, England) Vol. 59; no. 36; pp. 5463 - 5466
• Main Authors: Hoffmann, Arne, Schülke, Kai H, Hammer, Stephan C, Rentmeister, Andrea, Cornelissen, Nicolas V
• Format: Journal Article
• Published: 02.05.2023

Methyltransferases provide excellent specificity in late-stage alkylation of biomolecules. Their dependence on S -adenosyl- l -methionine (SAM) mandates efficient access to SAM analogues for biocatalytic applications. We directly compared halide methyltransferase (HMT) and methionine adenosyltransfe...