A self-activating electron transfer antibacterial strategy: CoO/TiO P-N heterojunctions combined with photothermal therapy
Implant-associated infections are significant impediments to successful surgical outcomes, often resulting from persistent bacterial contamination. It has been hypothesized that bacteria can transfer electrons to semiconductors with comparable potential to the biological redox potential (BRP). Build...
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Published in | Biomaterials science Vol. 12; no. 6; pp. 1573 - 1589 |
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Main Authors | , , , , , , |
Format | Journal Article |
Published |
12.03.2024
|
Online Access | Get full text |
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Abstract | Implant-associated infections are significant impediments to successful surgical outcomes, often resulting from persistent bacterial contamination. It has been hypothesized that bacteria can transfer electrons to semiconductors with comparable potential to the biological redox potential (BRP). Building on this concept, we developed an antibiotic-free bactericidal system, Co
3
O
4
/TiO
2
-Ti, capable of achieving real-time and sustainable bactericidal effects. Our study demonstrated that Co
3
O
4
/TiO
2
-Ti, possessing an appropriately set valence band, initiated charge transfer, reactive oxygen species (ROS) production, and membrane damage in adherent
Staphylococcus aureus
(
S. aureus
). Notably,
in vivo
experiments illustrated the remarkable antibacterial activity of Co
3
O
4
/TiO
2
-Ti, while promoting soft-tissue reconstruction and demonstrating excellent cytocompatibility. Transcriptomic analysis further revealed a down-regulation of aerobic respiration-associated genes and an up-regulation of ROS-associated genes in
S. aureus
in the presence of Co
3
O
4
/TiO
2
-Ti compared to Ti. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis and gene set enrichment analysis (GSEA) identified alterations in respiratory metabolism, oxidative phosphorylation, and the synthesis of amino acid in
S. aureus
cultured on Co
3
O
4
/TiO
2
-Ti. Furthermore, when combined with near-infrared (NIR) irradiation and photothermal therapy (PTT), Co
3
O
4
/TiO
2
-Ti eliminated 95.71% of floating and adherent
S. aureus in vitro
. The findings suggest that this antibiotic-free strategy holds substantial promise in enhancing implant sterilization capabilities, thereby contributing to the prevention and treatment of bacterial infections through bandgap engineering of implants and NIR irradiation.
An antibiotic-free bactericidal system combined with PTT was fabricated by introducing nanoscale Co
3
O
4
to a TiO
2
-Ti substrate (called Co
3
O
4
/TiO
2
-Ti). It manifested antimicrobial activity effectively in
in vitro
and
in vivo
experiments. |
---|---|
AbstractList | Implant-associated infections are significant impediments to successful surgical outcomes, often resulting from persistent bacterial contamination. It has been hypothesized that bacteria can transfer electrons to semiconductors with comparable potential to the biological redox potential (BRP). Building on this concept, we developed an antibiotic-free bactericidal system, Co
3
O
4
/TiO
2
-Ti, capable of achieving real-time and sustainable bactericidal effects. Our study demonstrated that Co
3
O
4
/TiO
2
-Ti, possessing an appropriately set valence band, initiated charge transfer, reactive oxygen species (ROS) production, and membrane damage in adherent
Staphylococcus aureus
(
S. aureus
). Notably,
in vivo
experiments illustrated the remarkable antibacterial activity of Co
3
O
4
/TiO
2
-Ti, while promoting soft-tissue reconstruction and demonstrating excellent cytocompatibility. Transcriptomic analysis further revealed a down-regulation of aerobic respiration-associated genes and an up-regulation of ROS-associated genes in
S. aureus
in the presence of Co
3
O
4
/TiO
2
-Ti compared to Ti. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis and gene set enrichment analysis (GSEA) identified alterations in respiratory metabolism, oxidative phosphorylation, and the synthesis of amino acid in
S. aureus
cultured on Co
3
O
4
/TiO
2
-Ti. Furthermore, when combined with near-infrared (NIR) irradiation and photothermal therapy (PTT), Co
3
O
4
/TiO
2
-Ti eliminated 95.71% of floating and adherent
S. aureus in vitro
. The findings suggest that this antibiotic-free strategy holds substantial promise in enhancing implant sterilization capabilities, thereby contributing to the prevention and treatment of bacterial infections through bandgap engineering of implants and NIR irradiation.
An antibiotic-free bactericidal system combined with PTT was fabricated by introducing nanoscale Co
3
O
4
to a TiO
2
-Ti substrate (called Co
3
O
4
/TiO
2
-Ti). It manifested antimicrobial activity effectively in
in vitro
and
in vivo
experiments. |
Author | Li, Miaomiao Sun, Nuo Chen, Siyuan Xie, Zhe Yang, Yuchen Wang, Chen Guo, Zhengnong |
AuthorAffiliation | Affiliated Hospital of Stomatology Nanjing Medical University Department of Prosthodontics Jiangsu Key Laboratory of Oral Diseases |
AuthorAffiliation_xml | – name: Department of Prosthodontics – name: Jiangsu Key Laboratory of Oral Diseases – name: Affiliated Hospital of Stomatology – name: Nanjing Medical University |
Author_xml | – sequence: 1 givenname: Siyuan surname: Chen fullname: Chen, Siyuan – sequence: 2 givenname: Zhe surname: Xie fullname: Xie, Zhe – sequence: 3 givenname: Yuchen surname: Yang fullname: Yang, Yuchen – sequence: 4 givenname: Nuo surname: Sun fullname: Sun, Nuo – sequence: 5 givenname: Zhengnong surname: Guo fullname: Guo, Zhengnong – sequence: 6 givenname: Miaomiao surname: Li fullname: Li, Miaomiao – sequence: 7 givenname: Chen surname: Wang fullname: Wang, Chen |
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Snippet | Implant-associated infections are significant impediments to successful surgical outcomes, often resulting from persistent bacterial contamination. It has been... |
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Title | A self-activating electron transfer antibacterial strategy: CoO/TiO P-N heterojunctions combined with photothermal therapy |
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