Redox tuning of the H-cluster by second coordination sphere amino acids in the sensory [FeFe] hydrogenase from

• Published in: Chemical science (Cambridge) Vol. 14; no. 13; pp. 3682 - 3692
• Main Authors: Chongdar, Nipa, Rodrguez-Maciá, Patricia, Reijerse, Edward J, Lubitz, Wolfgang, Ogata, Hideaki, Birrell, James A
• Format: Journal Article
• Published: 29.03.2023

[FeFe] hydrogenases are exceptionally active catalysts for the interconversion of molecular hydrogen with protons and electrons. Their active site, the H-cluster, is composed of a [4Fe-4S] cluster covalently linked to a unique [2Fe] subcluster. These enzymes have been extensively studied to understa...