Regioselective synthesis of N1-substituted-4-nitropyrazole-5-carboxylates the cyclocondensation of ethyl 4-(dimethylamino)-3-nitro-2-oxobut-3-enoate with substituted hydrazines
A simple and expeditious method for the regioselective synthesis of N1-substituted-4-nitropyrazole-5-carboxylates was developed. The method involves cyclocondensation of ethyl 4-(dimethylamino)-3-nitro-2-oxobut-3-enoate with a series of monosubstituted hydrazines to give N1-substituted-4-nitropyrazo...
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Published in | Organic & biomolecular chemistry Vol. 2; no. 48; pp. 9746 - 9752 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Published |
14.12.2022
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Online Access | Get full text |
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Summary: | A simple and expeditious method for the regioselective synthesis of N1-substituted-4-nitropyrazole-5-carboxylates was developed. The method involves cyclocondensation of ethyl 4-(dimethylamino)-3-nitro-2-oxobut-3-enoate with a series of monosubstituted hydrazines to give N1-substituted-4-nitropyrazole-5-carboxylates with excellent regioselectivity and good yields. Solvent effects on regioselectivity of the cyclocondensation were examined.
A simple and expeditious method for the regioselective synthesis of N1-substituted-4-nitropyrazole-5-carboxylates
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was developed with excellent regioselectivity and good yields. |
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Bibliography: | https://doi.org/10.1039/d2ob02006h Electronic supplementary information (ESI) available: Copies of the 1H, 13C and 2D NMR spectra of all products. See DOI |
ISSN: | 1477-0520 1477-0539 |
DOI: | 10.1039/d2ob02006h |