Theanine alleviates heat stress-induced impairment of immune function by regulating the p38 MAPK signalling pathway in mice
With the current trend of global warming, heat stress-induced impairment could seriously endanger human health. l -Theanine is a non-protein amino acid in tea with various biological activities, including immunoregulatory, anti-anxiety, and anti-oxidation. However, its effect on immune function unde...
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Published in | Food & function Vol. 14; no. 1; pp. 335 - 343 |
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Main Authors | , , , , , , |
Format | Journal Article |
Published |
03.01.2023
|
Online Access | Get full text |
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Summary: | With the current trend of global warming, heat stress-induced impairment could seriously endanger human health.
l
-Theanine is a non-protein amino acid in tea with various biological activities, including immunoregulatory, anti-anxiety, and anti-oxidation. However, its effect on immune function under heat stress and the underlying mechanism are currently unclear. In this study, male BALB/c mice were used as experimental objects to explore the effect of
l
-theanine on heat stress-induced changes in immune function and its mechanism. Three doses of
l
-theanine were used: low (100 mg kg
−1
d
−1
), medium (200 mg kg
−1
d
−1
), and high (400 mg kg
−1
d
−1
). Treatment with
l
-theanine could attenuate the heat stress-induced reductions in body weight and feed intake in mice, alleviate damage in the liver and jejunum, and inhibit the inflammatory factors IL-6, IL-1β, and TNF-α. Aspartate aminotransferase and alanine transaminase activity levels and the malondialdehyde content decreased, while the IgA, IgM, and IgG contents increased in response to
l
-theanine. It is possible that
l
-theanine affects the P38 signalling pathway and inhibits the increase in p-P65/P65 caused by the overexpression of HSP27 and regulation of PPAR-γ and Foxp3 proteins, thereby alleviating immune dysfunction caused by heat stress.
L-Theanine can regulate the immune system's function and inflammatory responses under heat stress
via
activation of the p38 MAPK signalling pathway. |
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Bibliography: | https://doi.org/10.1039/d2fo02775e Electronic supplementary information (ESI) available. See DOI |
ISSN: | 2042-6496 2042-650X |
DOI: | 10.1039/d2fo02775e |