and antitumor activity of novel half-sandwich ruthenium complexes containing quinoline derivative ligands

• Published in: Dalton transactions : an international journal of inorganic chemistry Vol. 52; no. 15; pp. 4728 - 4736
• Main Authors: He, Xiangdong, Chen, Jun, Kandawa-Shultz, Martha, Shao, Guoqiang, Wang, Yihong
• Format: Journal Article
• Published: 11.04.2023

A series of half-sandwich ruthenium complexes containing quinoline derivative ligands was synthesized, which had excellent antitumor toxicity toward a variety of cell lines and could localize lysosomes. The damage of lysosomes promotes the release of cathepsin B and initiates downstream apoptotic ca...