Lam. fruit preparations counteract the negative effects of a high-sugar diet on the glucose metabolism in
Solanum anguivi Lam. fruits (SALF) are traditionally consumed as a remedy for type 2 diabetes mellitus (T2DM). However, data regarding the potential anti-diabetic effect of SALF and its underlying mechanisms are scarce. As the fruit fly's energy metabolism has been suggested to be comparable wi...
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Published in | Food & function Vol. 12; no. 19; pp. 9238 - 9247 |
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Main Authors | , , , |
Format | Journal Article |
Published |
04.10.2021
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Abstract | Solanum anguivi
Lam. fruits (SALF) are traditionally consumed as a remedy for type 2 diabetes mellitus (T2DM). However, data regarding the potential anti-diabetic effect of SALF and its underlying mechanisms are scarce. As the fruit fly's energy metabolism has been suggested to be comparable with mammals including the secretion of insulin-like peptides, we fed
Drosophila melanogaster
a high-sugar diet (HSD) to induce a T2DM-like phenotype and subsequently exposed them to a HSD supplemented with SALF. Following, flies were analyzed for various biomarkers in relation to energy metabolism. The HSD-induced glucose levels were significantly down-regulated in flies exposed to a HSD supplemented with SALF. In addition, flies exposed to SALF-supplemented HSD exhibited a better survival in comparison to HSD-fed counterparts. Other parameters of the energy metabolism such as triglyceride levels, weights, and fitness were not affected by SALF supplementation. This was also true for the expression levels of the insulin-like-peptides 3 and 6 as well as for spargel, the
Drosophila
homolog of PPARγ-co-activator 1α, a central player in mitochondrial biogenesis. Overall, the present study shows that SALF significantly lowered the HSD-induced glucose levels and increased the survival while the biomarkers of the energy metabolism were not affected.
Solanum anguivi
Lam. fruits (SALF) are traditionally consumed as a remedy for type 2 diabetes mellitus (T2DM). |
---|---|
AbstractList | Solanum anguivi
Lam. fruits (SALF) are traditionally consumed as a remedy for type 2 diabetes mellitus (T2DM). However, data regarding the potential anti-diabetic effect of SALF and its underlying mechanisms are scarce. As the fruit fly's energy metabolism has been suggested to be comparable with mammals including the secretion of insulin-like peptides, we fed
Drosophila melanogaster
a high-sugar diet (HSD) to induce a T2DM-like phenotype and subsequently exposed them to a HSD supplemented with SALF. Following, flies were analyzed for various biomarkers in relation to energy metabolism. The HSD-induced glucose levels were significantly down-regulated in flies exposed to a HSD supplemented with SALF. In addition, flies exposed to SALF-supplemented HSD exhibited a better survival in comparison to HSD-fed counterparts. Other parameters of the energy metabolism such as triglyceride levels, weights, and fitness were not affected by SALF supplementation. This was also true for the expression levels of the insulin-like-peptides 3 and 6 as well as for spargel, the
Drosophila
homolog of PPARγ-co-activator 1α, a central player in mitochondrial biogenesis. Overall, the present study shows that SALF significantly lowered the HSD-induced glucose levels and increased the survival while the biomarkers of the energy metabolism were not affected.
Solanum anguivi
Lam. fruits (SALF) are traditionally consumed as a remedy for type 2 diabetes mellitus (T2DM). |
Author | Borsch, Christian Wagner, Anika E Nakitto, Aisha Musaazi Sebunya Rudloff, Silvia |
AuthorAffiliation | Justus-Liebig University Giessen Department of Food Technology and Nutrition School of Food Technology Nutrition and Bioengineering Makerere University Institute of Nutritional Sciences College of Agricultural and Environmental Sciences |
AuthorAffiliation_xml | – name: Makerere University – name: College of Agricultural and Environmental Sciences – name: Institute of Nutritional Sciences – name: School of Food Technology Nutrition and Bioengineering – name: Department of Food Technology and Nutrition – name: Justus-Liebig University Giessen |
Author_xml | – sequence: 1 givenname: Aisha Musaazi Sebunya surname: Nakitto fullname: Nakitto, Aisha Musaazi Sebunya – sequence: 2 givenname: Silvia surname: Rudloff fullname: Rudloff, Silvia – sequence: 3 givenname: Christian surname: Borsch fullname: Borsch, Christian – sequence: 4 givenname: Anika E surname: Wagner fullname: Wagner, Anika E |
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Lam. fruits (SALF) are traditionally consumed as a remedy for type 2 diabetes mellitus (T2DM). However, data regarding the potential... |
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