Total synthesis of pyrano[3,2-e]indole alkaloid fontanesine B by a double cyclization strategyElectronic supplementary information (ESI) available: Detailed experimental procedures and spectra data for all compounds, including scanned images of 1H and 13C NMR spectra. See DOI: 10.1039/c9ra02321f

• Main Authors: Itoh, Tomoki, Chiba, Yuusuke, Kawaguchi, Shunsuke, Koitaya, Yuki, Yoneta, Yuuma, Yamada, Koji, Abe, Takumi
• Format: Journal Article
• Language: English
• Published: 03.04.2019

The regioselective synthesis of pyrano[3,2- e ]indole alkaloid fontanesine B by two different cyclizations is described. The complete regioselectivity is controlled by the C4 Pictet-Spengler cyclization, in which an iminium ion acts as a transient directing (TDG) group. Furthermore, carbolines were...