Enantiocontrol by assembled attractive interactions in copper-catalyzed asymmetric direct alkynylation of α-ketoesters with terminal alkynes: OH O/sp3-CH O two-point hydrogen bonding combined with dispersive attractionsElectronic supplementary information (ESI) available: Representative experimental procedures, spectroscopic data, and computational details. See DOI: 10.1039/c8sc00527c

• Main Authors: Schwarzer, Martin C, Fujioka, Akane, Ishii, Takaoki, Ohmiya, Hirohisa, Mori, Seiji, Sawamura, Masaya
• Format: Journal Article
• Language: English
• Published: 04.04.2018

Copper-catalyzed asymmetric direct alkynylation of α-ketoesters with terminal alkynes with chiral prolinol-phosphine ligands, most preferably (α R ,2 S )-1-(2-dicyclohexylphosphinobenzyl)-α-neopentyl-2-pyrrolidinemethanol, afforded various enantioenriched chiral propargylic tertiary alcohols. Quantu...