A practically simple, catalyst free and scalable synthesis of -substituted ureas in water

• Published in: RSC advances Vol. 8; no. 38; pp. 21585 - 21595
• Main Authors: Tiwari, Lata, Kumar, Varun, Kumar, Bhuvesh, Mahajan, Dinesh
• Format: Journal Article
• Published: 13.06.2018

A practically simple, mild and efficient method is developed for the synthesis of N -substituted ureas by nucleophilic addition of amines to potassium isocyanate in water without organic co-solvent. Using this methodology, a variety of N -substituted ureas (mono-, di- and cyclic-) were synthesized i...