Bicyclic lactones and racemic mixtures of dimeric styrylpyrones from the leaves of Miliusa velutinaElectronic supplementary information (ESI) available: 1D NMR spectra of new compounds 1-11. CCDC 1415288 and 1062125. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7ra01609c
A unique class of eight bicyclic lactones with a C 18 carbon architecture, named velutinones A-H ( 1-8 ), three new dimeric styrylpyrones, velutinindimers A-C ( 9-11 ), five known compounds, the kawapyrone, yangonin ( 12 ), three flavonoids ( 13-15 ), and an acetogenin, cananginone H ( 16 ) were iso...
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| Main Authors | , , , , |
|---|---|
| Format | Journal Article |
| Language | English |
| Published |
11.05.2017
|
| Online Access | Get full text |
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| Summary: | A unique class of eight bicyclic lactones with a C
18
carbon architecture, named velutinones A-H (
1-8
), three new dimeric styrylpyrones, velutinindimers A-C (
9-11
), five known compounds, the kawapyrone, yangonin (
12
), three flavonoids (
13-15
), and an acetogenin, cananginone H (
16
) were isolated from the leaves of
Miliusa velutina
. The absolute configurations of
2
and
5
were assigned by Mosher's method, whereas ECD, optical rotations, and X-ray crystallographic analysis indicated the racemic nature of compounds
10
and
11
. Compounds
2-4
and
7-11
showed antimalarial activity with IC
50
values in the range of 5.4-10.0 μM. Moreover,
1-4
and
6-8
displayed cytotoxicity against the KB, MCF7, and NCI-H187 cancer cell lines and Vero cell lines with IC
50
values in the range of 4.0-24.1 μM.
Eight new bicyclic lactones and three new dimeric styrylpyrones from the leaves of
Miliusa velutina
were reported with their bioactivities. |
|---|---|
| Bibliography: | CCDC For ESI and crystallographic data in CIF or other electronic format see DOI 1415288 1062125 10.1039/c7ra01609c and Electronic supplementary information (ESI) available: 1D NMR spectra of new compounds 1-11 |
| ISSN: | 2046-2069 |
| DOI: | 10.1039/c7ra01609c |