Encapsulation property of hyperbranched polyglycerols as prospective drug delivery systemsElectronic supplementary information (ESI) available. See DOI: 10.1039/c7py01419h
Hyperbranched polyglycerols (hbPGs) were investigated as nanocarriers to encapsulate and deliver guest molecules. 1 H NMR titration and 1 H- 1 H NOESY and fluorescence experiments were performed to study molecular interactions between hbPGs and Rhodamine B (RB). The results show that RB is entrapped...
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| Main Authors | , , , , , |
|---|---|
| Format | Journal Article |
| Published |
16.01.2018
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| Online Access | Get full text |
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| Abstract | Hyperbranched polyglycerols (hbPGs) were investigated as nanocarriers to encapsulate and deliver guest molecules.
1
H NMR titration and
1
H-
1
H NOESY and fluorescence experiments were performed to study molecular interactions between hbPGs and Rhodamine B (RB). The results show that RB is entrapped in hbPGs by electrostatic interactions with hbPG etheric chains. Hydrogen bonds between etheric chains and the carboxyl group of RB induce the rotation of the phenyl
vs.
xanthene ring, further stabilizing the complex. hbPGs and RB interactions in water were also evaluated and compared to the interaction in
d
6
-DMSO. The results reveal that the terminal glycerol units of hbPGs form a tight shell outside the interior parts in aqueous solution.
1
H-
1
H NOESY studies of hbPGs with 5-Fu using surface modification suggest that this layer might be a main factor affecting the encapsulation and release of guest molecules.
Hyperbranched polyglycerols (hbPGs) were investigated as nanocarriers to encapsulate and deliver guest molecules. |
|---|---|
| AbstractList | Hyperbranched polyglycerols (hbPGs) were investigated as nanocarriers to encapsulate and deliver guest molecules.
1
H NMR titration and
1
H-
1
H NOESY and fluorescence experiments were performed to study molecular interactions between hbPGs and Rhodamine B (RB). The results show that RB is entrapped in hbPGs by electrostatic interactions with hbPG etheric chains. Hydrogen bonds between etheric chains and the carboxyl group of RB induce the rotation of the phenyl
vs.
xanthene ring, further stabilizing the complex. hbPGs and RB interactions in water were also evaluated and compared to the interaction in
d
6
-DMSO. The results reveal that the terminal glycerol units of hbPGs form a tight shell outside the interior parts in aqueous solution.
1
H-
1
H NOESY studies of hbPGs with 5-Fu using surface modification suggest that this layer might be a main factor affecting the encapsulation and release of guest molecules.
Hyperbranched polyglycerols (hbPGs) were investigated as nanocarriers to encapsulate and deliver guest molecules. |
| Author | Wang, Ruibin Wu, Haigang Yin, Ting Li, Ke Chen, Yantian Jing, Lili |
| AuthorAffiliation | Instrumental Analysis Center School of Pharmacy School of Biomedical Engineering School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University University of Michigan-Shanghai Jiao Tong University Joint Institute |
| AuthorAffiliation_xml | – name: School of Biomedical Engineering – name: Shanghai Jiao Tong University – name: School of Pharmacy – name: School of Electronic Information and Electrical Engineering – name: University of Michigan-Shanghai Jiao Tong University Joint Institute – name: Instrumental Analysis Center |
| Author_xml | – sequence: 1 givenname: Haigang surname: Wu fullname: Wu, Haigang – sequence: 2 givenname: Ting surname: Yin fullname: Yin, Ting – sequence: 3 givenname: Ke surname: Li fullname: Li, Ke – sequence: 4 givenname: Ruibin surname: Wang fullname: Wang, Ruibin – sequence: 5 givenname: Yantian surname: Chen fullname: Chen, Yantian – sequence: 6 givenname: Lili surname: Jing fullname: Jing, Lili |
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| Snippet | Hyperbranched polyglycerols (hbPGs) were investigated as nanocarriers to encapsulate and deliver guest molecules.
1
H NMR titration and
1
H-
1
H NOESY and... |
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| Title | Encapsulation property of hyperbranched polyglycerols as prospective drug delivery systemsElectronic supplementary information (ESI) available. See DOI: 10.1039/c7py01419h |
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