Ligand-free, palladacycle-facilitated Suzuki coupling of hindered 2-arylbenzothiazole derivatives yields potent and selective COX-2 inhibitorsElectronic supplementary information (ESI) available. See DOI: 10.1039/c7ob02386c

• Main Authors: Elsayed, Mohamed S. A, Chang, Siran, Cushman, Mark
• Format: Journal Article
• Published: 19.12.2017

A similarity search and molecular modeling study suggested the 2′-aryl-2-arylbenzothiazole framework as a novel scaffold for the design of COX-2-selective inhibitors. Conventional Suzuki coupling conditions did not furnish the designed compounds in good yield from 2′-bromo-2-arylbenzothiazole as the...