Lasiodiplactone A, a novel lactone from the mangrove endophytic fungus Lasiodiplodia theobromae ZJ-HQ1Electronic supplementary information (ESI) available: HRESIMS, 1D and 2D NMR spectra, and detailed Experimental section, as well as crystallographic data. See DOI: 10.1039/c7ob01657c

• Main Authors: Chen, Senhua, Liu, Zhaoming, Liu, Hongju, Long, Yuhua, Chen, Dongni, Lu, Yongjun, She, Zhigang
• Format: Journal Article
• Language: English
• Published: 02.08.2017
• ISSN: 1477-0520; 1477-0539
• DOI: 10.1039/c7ob01657c

Lasiodiplactone A ( 1 ), an unprecedented lactone, was obtained from the mangrove endophytic fungus Lasiodiplodia theobromae ZJ-HQ1. The structure of 1 was established by analysis of NMR spectroscopic data and electronic circular dichroism (ECD) spectra. Lasiodiplactone A ( 1 ) was the first example of lactone that possesses a unique tetracyclic system (12/6/6/5) of RAL 12 (12-membered β-resorcylic acid lactone) with a pyran ring and a furan ring. A possible biogenetic pathway for 1 was proposed. Compound 1 showed anti-inflammatory activity by inhibiting nitric oxide (NO) production in lipopolysaccharide activated in RAW264.7 cells with IC 50 value of 23.5 μM and exhibited potential α-glucosidase inhibitory activity with IC 50 values of 29.4 μM. Lasiodiplactone A ( 1 ), an unprecedented lactone, was obtained from the mangrove endophytic fungus Lasiodiplodia theobromae ZJ-HQ1.