Iron(iii) coordination properties of ladanein, a flavone lead with a broad-spectrum antiviral activityElectronic supplementary information (ESI) available: Absorption spectrophotometric titrations of the ligands and the ferric complexes; ESI-MS characterization; oxidation kinetics of the ligands monitored by absorption spectrophotometry; ICP-MS data. See DOI: 10.1039/c7nj04867j
Ladanein, a 5,6,7-trihydroxylayted flavone was recently shown to display potent antiviral activities toward enveloped virus particles ( e.g. , hepatitis C virus, human immunodeficiency virus, vesicular stomatitis virus). Fe( iii ) coordination and pH were suggested to be critical for bioactivation s...
Saved in:
| Main Authors | , , , , |
|---|---|
| Format | Journal Article |
| Language | English |
| Published |
14.05.2018
|
| Online Access | Get full text |
Cover
Loading…
| Abstract | Ladanein, a 5,6,7-trihydroxylayted flavone was recently shown to display potent antiviral activities toward enveloped virus particles (
e.g.
, hepatitis C virus, human immunodeficiency virus, vesicular stomatitis virus). Fe(
iii
) coordination and pH were suggested to be critical for bioactivation steps triggering host cell entry inhibition. The Fe(
iii
) complexation properties of ladanein and related analogues, such as negletein and salvigenin, were then studied in solution under quasi-physiological conditions using physico-chemical tools and provided important insights into their stability/reactivity in solution.
The Fe(
iii
) complexation properties of ladanein, a potent antiviral flavone, and related analogues (negletein and salvigenin), have been studied in solution under quasi-physiological conditions using physico-chemical tools and provided important insights into their stability/reactivity in solution. |
|---|---|
| AbstractList | Ladanein, a 5,6,7-trihydroxylayted flavone was recently shown to display potent antiviral activities toward enveloped virus particles (
e.g.
, hepatitis C virus, human immunodeficiency virus, vesicular stomatitis virus). Fe(
iii
) coordination and pH were suggested to be critical for bioactivation steps triggering host cell entry inhibition. The Fe(
iii
) complexation properties of ladanein and related analogues, such as negletein and salvigenin, were then studied in solution under quasi-physiological conditions using physico-chemical tools and provided important insights into their stability/reactivity in solution.
The Fe(
iii
) complexation properties of ladanein, a potent antiviral flavone, and related analogues (negletein and salvigenin), have been studied in solution under quasi-physiological conditions using physico-chemical tools and provided important insights into their stability/reactivity in solution. |
| Author | Novodomska, A Jacquemin, D Martin-Benlloch, X Davioud-Charvet, E Elhabiri, M |
| AuthorAffiliation | UMR 7042 Université de Haute-Alsace LIMA Ceisam Laboratory CNRS University of Heidelberg University of Nantes UMR CNRS 6230 Université de Strasbourg Biochemistry Center (BZH) |
| AuthorAffiliation_xml | – name: Ceisam Laboratory – name: University of Heidelberg – name: Université de Haute-Alsace – name: CNRS – name: UMR CNRS 6230 – name: Université de Strasbourg – name: UMR 7042 – name: Biochemistry Center (BZH) – name: LIMA – name: University of Nantes |
| Author_xml | – sequence: 1 givenname: X surname: Martin-Benlloch fullname: Martin-Benlloch, X – sequence: 2 givenname: A surname: Novodomska fullname: Novodomska, A – sequence: 3 givenname: D surname: Jacquemin fullname: Jacquemin, D – sequence: 4 givenname: E surname: Davioud-Charvet fullname: Davioud-Charvet, E – sequence: 5 givenname: M surname: Elhabiri fullname: Elhabiri, M |
| BookMark | eNqFkUFvEzEQhRdUJFrKhXul4dZKbLtL0g1pTqgEkUPVSuk9mtizZILXY43d0CB-PM4GiUMFnDz2m3nvk-eoOPDiqSje1NV5XQ3GF2bk19XwQzNaPy8O60EzLsfvm_og1_VwWFaXw-ZlcRTjuqrqetTUh89-zlT8KTOfgRFRyx4Ti4egEkgTUwRpwaFFT-zfAULrcJNDwRFa-M5pld-WKmjLGMgkfegAfeINKzpAs6vSdup2kng2EB9CcNSRT6hbYN-KdvvM0-l8dga4QXa4dHQFH5dRNPTa3lvCSpJ0lDQbJU7aD_aIaZWR-Ct6G3O-7e8t6a7RSJcTHylOICeUN3MwK9SMRso_eocJyCPbPcU39pTYPDHtMn0SJQvLLeDfybYTmF3f7VKyIZ7DnAg-3c6u4OmOjosXLbpIr3-fr4qTz9P76y-lRrMIyl3-ocWf9sH_9bf_0hfBtoNft827OQ |
| ContentType | Journal Article |
| DOI | 10.1039/c7nj04867j |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry |
| EISSN | 1369-9261 |
| EndPage | 887 |
| ExternalDocumentID | c7nj04867j |
| GroupedDBID | -JG 0-7 1TJ 705 70J 70~ 7~J AAEMU ABGFH ACLDK ADSRN AEFDR AFVBQ AGSTE AUDPV BSQNT C6K EE0 EF- GNO H~N IDZ J3I R7B R7C R7D RCNCU RPMJG RRC RSCEA SKA SKF SKH SLH VH6 |
| ID | FETCH-rsc_primary_c7nj04867j3 |
| ISSN | 1144-0546 |
| IngestDate | Mon Jan 28 17:14:27 EST 2019 Wed Jun 05 04:42:35 EDT 2019 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-rsc_primary_c7nj04867j3 |
| Notes | 10.1039/c7nj04867j Electronic supplementary information (ESI) available: Absorption spectrophotometric titrations of the ligands and the ferric complexes; ESI-MS characterization; oxidation kinetics of the ligands monitored by absorption spectrophotometry; ICP-MS data. See DOI |
| PageCount | 14 |
| ParticipantIDs | rsc_primary_c7nj04867j |
| ProviderPackageCode | J3I ACLDK RRC 7~J AEFDR 70~ VH6 GNO RCNCU SLH 70J EE0 RSCEA AFVBQ C6K H~N 0-7 IDZ RPMJG 1TJ SKA -JG AGSTE AUDPV EF- BSQNT SKF SKH ADSRN ABGFH 705 R7B R7D AAEMU R7C |
| PublicationCentury | 2000 |
| PublicationDate | 20180514 |
| PublicationDateYYYYMMDD | 2018-05-14 |
| PublicationDate_xml | – month: 5 year: 2018 text: 20180514 day: 14 |
| PublicationDecade | 2010 |
| PublicationYear | 2018 |
| References_xml | – issn: 2013 publication-title: Flavone derivatives and their use doi: Pietschmann Haid Gentzsch Grethe Davioud-Charvet Lanfranchi Elhabiri Benlloch-Martin – issn: 2010 doi: Haid – issn: 2009 publication-title: Gaussian 09 doi: Frisch Trucks Schlegel Scuseria Robb Cheeseman Scalmani Barone Petersson Nakatsuji Li Caricato Marenich Bloino Janesko Gomperts Mennucci Hratchian Ortiz Izmaylov Sonnenberg Williams-Young Ding Lipparini Egidi Goings Peng Petrone Henderson Ranasinghe Zakrzewski Gao Rega Zheng Liang Hada Ehara Toyota Fukuda Hasegawa Ishida Nakajima Honda Kitao Nakai Vreven Throssell Montgomery, Jr. Peralta Ogliaro Bearpark Heyd Brothers Kudin Staroverov Keith Kobayashi Normand Raghavachari Rendell Burant Iyengar Tomasi Cossi Millam Klene Adamo Cammi Ochterski Martin Morokuma Farkas Foresman Fox – issn: 2005 publication-title: Chélation de métaux de transition par des polyphénols du régime alimentaire doi: Carrër – issn: 1962 end-page: 107 publication-title: The Chemistry of Flavonoid Compounds doi: Jurd |
| SSID | ssj0011761 |
| Score | 4.531996 |
| Snippet | Ladanein, a 5,6,7-trihydroxylayted flavone was recently shown to display potent antiviral activities toward enveloped virus particles (
e.g.
, hepatitis C... |
| SourceID | rsc |
| SourceType | Enrichment Source Publisher |
| StartPage | 874 |
| Title | Iron(iii) coordination properties of ladanein, a flavone lead with a broad-spectrum antiviral activityElectronic supplementary information (ESI) available: Absorption spectrophotometric titrations of the ligands and the ferric complexes; ESI-MS characterization; oxidation kinetics of the ligands monitored by absorption spectrophotometry; ICP-MS data. See DOI: 10.1039/c7nj04867j |
| Volume | 42 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9pAEN7mcWgvUV9RkzTVHHpI5DoNYGIIp0CpQtS0lUIlbmj9ap0YLzIEhag_vjO76zVPqe0FwVper5n9vN-Ov5lh7D1S0BISB9em9F42zpCSXasFNTvCuYHLg48UnwKcr7-eXf5wrnrV3sbmdEa1dD_2TvzHlXEl_2NVbEO7UpTsP1jWdIoN-B3ti59oYfz8Kxt3MqnkiOOYNve-wI1krLx7pLsakmRa5ZRNeMBTXdaSW1HCJwLJZYL21cFtlpcJHtgy7jIjvXJKVSUoeJ8CH6i-RLuolzOiSqBKdZ5R2KAJgCS62r7p0GD4hMcJhWVJz6M3Epl6NqkriOEvMRYDqublW3gvWSHIIyKcxD8pAtmoOyNKH-kr-Xv4QCq-poXXsa9vKHBZJ5x-1DqVpiUeYlUpyrpDDi3zUC90PJBPskyxb75-dFPqrtP6TlciLe0JPltD69O3jnSkyFwClEjVd9NbmVTwtnDwU3YGuxmmCbIF6brqGb-7mIhADEZ3fM6XfMV9XKMHykhGh00xB-I-sEkWMVEvjtqznppSjUQGKkJWLy64ecU27XINVVvlrG7Xyyohfb4iOeUl5I00N3FmmYqiKkuL4Mpbn08qXhzcZNtlfEbj4rB90e52vphXcCVXJRvOB53n9q3UPxZnIyPL8ko5kpF1n7MdvZWCC4WLF2wjTF-yp628guGrJ78JH0eIjmOYxQYU2AARQY6ND8BBIwMIGUDIwLZ5ZIBBBiwjA-aQATPIgCOcr8dgUHEOBSZgGRNQYIKGiFMX9NTF6wfyt8IEGEw0QCECFhHRAIMHyPGw2KnBA3hT4OtHNm2AQgNINACiARAN57Bss9fs8HO727q00XL9ocpp0y8OV3bZVop_9RsGpz5uDsIqd7xKFcmu67nuKa9EJYdXy54X1vbY7uo-9tj-6gP9YRDtrzvrgD0rYPOWbaFVw0Ok_GPvnZ6cfwDsUBec |
| link.rule.ids | 315,783,787,27936,27937 |
| linkProvider | Royal Society of Chemistry |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Iron%28iii%29+coordination+properties+of+ladanein%2C+a+flavone+lead+with+a+broad-spectrum+antiviral+activityElectronic+supplementary+information+%28ESI%29+available%3A+Absorption+spectrophotometric+titrations+of+the+ligands+and+the+ferric+complexes%3B+ESI-MS+characterization%3B+oxidation+kinetics+of+the+ligands+monitored+by+absorption+spectrophotometry%3B+ICP-MS+data.+See+DOI%3A+10.1039%2Fc7nj04867j&rft.au=Martin-Benlloch%2C+X&rft.au=Novodomska%2C+A&rft.au=Jacquemin%2C+D&rft.au=Davioud-Charvet%2C+E&rft.date=2018-05-14&rft.issn=1144-0546&rft.eissn=1369-9261&rft.volume=42&rft.issue=1&rft.spage=874&rft.epage=887&rft_id=info:doi/10.1039%2Fc7nj04867j&rft.externalDocID=c7nj04867j |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1144-0546&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1144-0546&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1144-0546&client=summon |