Tetracarboxylic acids on a thiacalixarene scaffold: synthesis and binding of dopamine hydrochlorideElectronic supplementary information (ESI) available. See DOI: 10.1039/c7nj03953k

• Main Authors: Mostovaya, O. A, Padnya, P. L, Vavilova, A. A, Shurpik, D. N, Khairutdinov, B. I, Mukhametzyanov, T. A, Khannanov, A. A, Kutyreva, M. P, Stoikov, I. I
• Format: Journal Article
• Language: English
• Published: 18.12.2017
• ISSN: 1144-0546; 1369-9261
• DOI: 10.1039/c7nj03953k

For the first time thiacalix[4]arene derivatives in 1,3- alternate conformation simultaneously containing amide, carboxyl and hydroxyl groups capable of forming 1 : 1 stoichiometry complexes with dopamine hydrochloride were obtained. The efficiency of dopamine hydrochloride binding was evaluated by a number of spectral methods. Using the methods of fluorescent, UV-Vis and NMR spectroscopy, the mechanism of interaction of the synthesized macrocycles with dopamine has been studied. It was shown that quenching of dopamine fluorescence by the studied macrocycles is carried out through a static mechanism. Tetracarboxylic acids based on thiacalix[4]arene in 1,3- alternate conformation quench fluorescence of dopamine hydrochloride according to the static mechanism.