MRI-guided tumor chemo-photodynamic therapy with Gd/Pt bifunctionalized porphyrinElectronic supplementary information (ESI) available. See DOI: 10.1039/c7bm00431a

Porphyrin derivatives have been widely applied in MR imaging and photodynamic cancer therapy. We here report a novel Gd/Pt bifunctionalized porphyrin derivative (Gd/Pt-P1) for MRI-guided chemo-photodynamic cancer therapy. Gd/Pt-P1 was prepared from tetra(4-pyridyl) porphyrin (P1) via step by step co...

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Main Authors Wu, Bo, Li, Xiao-Qi, Huang, Tong, Lu, Shu-Ting, Wan, Bing, Liao, Ru-Fang, Li, Yu-Shuang, Baidya, Aju, Long, Qing-Yun, Xu, Hai-Bo
Format Journal Article
LanguageEnglish
Published 22.08.2017
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Abstract Porphyrin derivatives have been widely applied in MR imaging and photodynamic cancer therapy. We here report a novel Gd/Pt bifunctionalized porphyrin derivative (Gd/Pt-P1) for MRI-guided chemo-photodynamic cancer therapy. Gd/Pt-P1 was prepared from tetra(4-pyridyl) porphyrin (P1) via step by step coordination to cisplatin and gadolinium (Gd( iii )). Gd/Pt-P1 showed a particularly high synergetic chemo-photodynamic antitumor effect in vivo with a tumor inhibition rate (TIR) of 96.6% and excellent MR imaging performance. Gd/Pt bifunctionalized porphyrin derivative was synthesized for MRI-guided highly synergetic chemo-photodynamic therapy of cancer.
AbstractList Porphyrin derivatives have been widely applied in MR imaging and photodynamic cancer therapy. We here report a novel Gd/Pt bifunctionalized porphyrin derivative (Gd/Pt-P1) for MRI-guided chemo-photodynamic cancer therapy. Gd/Pt-P1 was prepared from tetra(4-pyridyl) porphyrin (P1) via step by step coordination to cisplatin and gadolinium (Gd( iii )). Gd/Pt-P1 showed a particularly high synergetic chemo-photodynamic antitumor effect in vivo with a tumor inhibition rate (TIR) of 96.6% and excellent MR imaging performance. Gd/Pt bifunctionalized porphyrin derivative was synthesized for MRI-guided highly synergetic chemo-photodynamic therapy of cancer.
Author Wan, Bing
Huang, Tong
Baidya, Aju
Liao, Ru-Fang
Li, Yu-Shuang
Wu, Bo
Long, Qing-Yun
Lu, Shu-Ting
Li, Xiao-Qi
Xu, Hai-Bo
AuthorAffiliation College of Chemistry
Tongji Medical College
Wuhan University
Central China Normal University
Huazhong University of Science and Technology
Zhongnan Hospital of Wuhan University
Department of Radiology
Union Hospital
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